Publication Name	World Journal of Hepatology
Manuscript ID	38680
Country	Italy

Received	2018-03-08 10:32
Peer-Review Started	2018-03-08 16:52
To Make the First Decision	2018-03-19 00:41
Return for Revision	2018-03-23 01:57
Revised	2018-03-30 21:46
Second Decision	2018-05-11 10:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-05-11 17:42
Articles in Press	2018-05-11 17:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-25 05:43
Publish the Manuscript Online	2018-06-28 02:47

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Responsibility of hepatitis C virus in the development of hepatocellular carcinoma: From molecular alterations to possible solutions
Manuscript Source	Unsolicited Manuscript
All Author List	Gaetano Bertino, Giulia Malaguarnera, Evelise Frazzetto, Alice Sciuto, Gaetano Inserra, Guido Nicola Zanghi and Michele Malaguarnera
ORCID	Author(s) ORCID Number Gaetano Bertino http://orcid.org/0000-0002-4557-2649 Giulia Malaguarnera http://orcid.org/0000-0003-3655-4307 Evelise Frazzetto http://orcid.org/56020556000 Alice Sciuto http://orcid.org/000000000 Gaetano Inserra http://orcid.org/0000-0002-0986-402X Guido Nicola Zanghi http://orcid.org/0000-0003-3665-8325 Michele Malaguarnera http://orcid.org/0000-0002-7145-6377
Funding Agency and Grant Number
Corresponding Author	Gaetano Bertino, MD, Associate Professor, Hepatology Unit, Department of Clinical and Experimental Medicine, University of Catania, Policlinico “G. Rodolico”, Via S. Sofia n.78, Catania 95123, Italy. gaetanobertinounict@gmail.com
Key Words	Hepatitis C virus; Hepatocellular carcinoma; Inflammation; Fibrosis; Insulin-resistance; Oxidative stress; Direct acting antivirals
Core Tip	The hepatitis C virus (HCV) is able to contribute, both directly and indirectly, to the development of hepatocellular carcinoma (HCC). The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents, an extraordinary opportunity for true prevention of the development of HCV-related HCC.
Publish Date	2018-06-28 02:47
Citation	Bertino G, Malaguarnera G, Frazzetto E, Sciuto A, Inserra G, Zanghì GN, Malaguarnera M. Responsibility of hepatitis C virus in the development of hepatocellular carcinoma: From molecular alterations to possible solutions. World J Hepatol 2018; 10(6): 448-451
URL	http://www.wjgnet.com/1948-5182/full/v10/i6/448.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i6.448

Full Article (PDF)	WJH-10-448.pdf
Full Article (Word)	WJH-10-448.doc
Manuscript File	38680-Review.docx
Answering Reviewers	38680-Answering reviewers.pdf
Audio Core Tip	38680-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	38680-Conflict-of-interest statement.pdf
Copyright License Agreement	38680-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	38680-Language certificate.pdf
Peer-review Report	38680-Peer-review(s).pdf
Scientific Editor Work List	38680-Scientific editor work list.pdf