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Articles Published Processes
7/27/2018 4:31:20 PM | Browse: 1329 | Download: 2025
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Received |
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2018-03-11 06:38 |
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Peer-Review Started |
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2018-03-11 10:01 |
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To Make the First Decision |
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2018-03-29 01:26 |
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Return for Revision |
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2018-03-31 10:19 |
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Revised |
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2018-04-06 05:24 |
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Second Decision |
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2018-04-09 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-04-09 15:15 |
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Articles in Press |
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2018-04-09 15:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-05-08 16:29 |
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Typeset the Manuscript |
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2018-07-25 03:10 |
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Publish the Manuscript Online |
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2018-07-27 16:31 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Neha Vithal Bhilare, Suneela Sunil Dhaneshwar and Kakasaheb Ramoo Mahadik |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Suneela Sunil Dhaneshwar, PhD, Professor, Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Maharashtra 411038, Erandwane, India. suneeladhaneshwar@rediffmail.com |
| Key Words |
Aminothiols; antioxidants; N-acetyl cysteine; N-(2-mercaptopropionyl) glycine; isoniazid; L-methionine; liver injury; tuberculosis |
| Core Tip |
To overcome the deleterious effects caused by long-term use of isoniazid (INH), a novel hepatoprotective prodrug strategy was developed by integrating the antioxidant property of aminothiols with INH moiety to improve its therapeutic safety. The anticipated prodrugs were synthesized using facile method of synthesis, wherein aminothiols were tethered to the INH molecule via biocleavable amide linkage. Upon hepatoprotective potential assessment, the prodrug NI displayed noteworthy effects, whereas prodrugs MGI and MI exhibited moderate effects. The findings of this study strongly suggest that concept-based design of hepatoprotective prodrugs can be applied effectively in reversing toxic effects of INH and its metabolites on liver. |
| Publish Date |
2018-07-27 16:31 |
| Citation |
Bhilare NV, Dhaneshwar SS, Mahadik KR. Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation. World J Hepatol 2018; 10(7): 496-508 |
| URL |
http://www.wjgnet.com/1948-5182/full/v10/i7/496.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v10.i7.496 |
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