Publication Name	World Journal of Gastroenterology
Manuscript ID	38690
Country	Japan

Received	2018-03-17 07:52
Peer-Review Started	2018-03-17 13:35
To Make the First Decision	2018-04-19 00:38
Return for Revision	2018-04-24 07:29
Revised	2018-05-09 13:50
Second Decision	2018-06-21 08:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-21 17:54
Articles in Press	2018-06-21 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-07-25 03:15
Publish the Manuscript Online	2018-07-27 06:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib
Manuscript Source	Unsolicited Manuscript
All Author List	Masanori Ochi, Toshiro Kamoshida, Atsushi Ohkawara, Haruka Ohkawara, Nobushige Kakinoki, Shinji Hirai and Akinori Yanaka
ORCID	Author(s) ORCID Number Masanori Ochi http://orcid.org/0000-0003-0850-6076 Toshiro Kamoshida http://orcid.org/0000-0003-4930-1018 Atsushi Ohkawara http://orcid.org/0000-0003-1764-565X Haruka Ohkawara http://orcid.org/0000-0001-8427-5826 Nobushige Kakinoki http://orcid.org/0000-0002-1522-2226 Shinji Hirai http://orcid.org/0000-0001-7141-0240 Akinori Yanaka http://orcid.org/0000-0001-7967-5665
Funding Agency and Grant Number
Corresponding Author	Masanori Ochi, MD, Doctor, Department of Gastroenterology, Hitachi General Hospital, 2-1-1, Jonancho, Hitachi 317-0077, Japan. maochi-tei@umin.ac.jp
Key Words	Hepatocellular carcinoma; Surrogate marker; Multikinase inhibitor-associated hand-foot skin reaction; Sorafenib; Intervention by pharmacists
Core Tip	Sorafenib is an oral anticancer drug associated with a high incidence of adverse reactions. However, no studies have evaluated its therapeutic efficacy under improved adherence. A surrogate marker of significant improvement in overall survival under improved adher­ence in advanced hepatocellular carcinoma patients after the introduction of sorafenib was multikinase inhibitor-associated hand-foot skin reaction. Intervention by healthcare providers, including pharmacists specializing in cancer treatment, has improved patient adherence, contributing to the true response to sorafenib treatment.
Publish Date	2018-07-27 06:43
Citation	Ochi M, Kamoshida T, Ohkawara A, Ohkawara H, Kakinoki N, Hirai S, Yanaka A. Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib. World J Gastroenterol 2018; 24(28): 3155-3162
URL	http://www.wjgnet.com/1007-9327/full/v24/i28/3155.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i28.3155

Full Article (PDF)	WJG-24-3155.pdf
Manuscript File	38690-Review.docx
Answering Reviewers	38690-Answering reviewers.pdf
Audio Core Tip	38690-Audio core tip.MP3
Biostatistics Review Certificate	38690-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	38690-Conflict-of-interest statement.pdf
Copyright License Agreement	38690-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	38690-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	38690-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	38690-Language certificate.pdf
Peer-review Report	38690-Peer-review(s).pdf
Scientific Misconduct Check	38690-Scientific misconduct check.pdf
Scientific Editor Work List	38690-Scientific editor work list.pdf