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5/11/2018 10:51:26 AM | Browse: 328 | Download: 161
Publication Name World Journal of Gastroenterology
Manuscript ID 38796
Country/Territory Romania
Received
2018-03-20 02:44
Peer-Review Started
2018-03-20 07:29
To Make the First Decision
2018-04-03 00:53
Return for Revision
2018-04-10 11:26
Revised
2018-04-12 10:35
Second Decision
2018-04-23 05:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-04-23 16:32
Articles in Press
2018-04-23 16:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-05-10 08:54
Publish the Manuscript Online
2018-05-11 10:51
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title New therapeutic options opened by the molecular classification of gastric cancer
Manuscript Source Invited Manuscript
All Author List Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu and Carmen Cristina Diaconu
ORCID
Author(s) ORCID Number
Mihaela Chivu-Economescu http://orcid.org/0000-0001-7512-4700
Lilia Matei http://orcid.org/0000-0003-4479-655X
Laura Georgiana Necula http://orcid.org/0000-0001-6531-7939
Denisa Laura Dragu http://orcid.org/0000-0002-5868-2636
Coralia Bleotu http://orcid.org/0000-0002-9031-338X
Carmen Cristina Diaconu http://orcid.org/0000-0002-2259-1425
Funding Agency and Grant Number
Corresponding author Mihaela Chivu-Economescu, PhD, Senior Researcher, Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest 030304, Romania. mihaela.economescu@virology.ro
Keywords Gastric cancer; Molecular classification; Immunotherapy; Targeted therapy; Clinical trials
Core Tip A new molecular classification of gastric cancer (GC) became available after publication of three landmark studies: The Cancer Genome Atlas, “Singapore-Duke” study, and Asian Cancer Research Group, allowing patient selection for specific targeted therapy. The Epstein-Barr virus positive, microsatellite stable TP53-active or microsatellite-unstable tumors subtypes presents tumour infiltrating patterns with overexpression of PD-1, PD-L1, PDL-2. Preliminary data show high response rate to immunotherapy and open new avenues to gene therapy. Currently effective therapies for diffuse GC are lacking. Mutations in e-cadherin and Ras homolog family member A genes, or Claudin-18-ARHGAP6/26 fusions may be exploited as therapeutic targets. The only targeted therapies approved so far for chromosomal instability and microsatellite stable TP53-inactive subtypes of GC are trastuzumab and ramucirumab (HER2 and VEGFR2 inhibitors).
Publish Date 2018-05-11 10:51
Citation Chivu-Economescu M, Matei L, Necula LG, Dragu DL, Bleotu C, Diaconu CC. New therapeutic options opened by the molecular classification of gastric cancer. World J Gastroenterol 2018; 24(18): 1942-1961
Url http://www.wjgnet.com/1007-9327/full/v24/i18/1942.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i18.1942
Full Article (PDF) WJG-24-1942.pdf
Full Article (Word) WJG-24-1942.doc
Manuscript File 38796-Review.docx
Answering Reviewers 38796-Answering reviewers.pdf
Audio Core Tip 38796-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 38796-Conflict-of-interest statement.pdf
Copyright License Agreement 38796-Copyright license agreement.pdf
Peer-review Report 38796-Peer-review(s).pdf
Scientific Misconduct Check 38796-Scientific misconduct check.pdf
Scientific Editor Work List 38796-Scientific editor work list.pdf