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Articles Published Processes
5/11/2018 10:51:26 AM | Browse: 998 | Download: 1273
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Received |
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2018-03-20 02:44 |
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Peer-Review Started |
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2018-03-20 07:29 |
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To Make the First Decision |
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2018-04-03 00:53 |
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Return for Revision |
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2018-04-10 11:26 |
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Revised |
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2018-04-12 10:35 |
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Second Decision |
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2018-04-23 05:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-04-23 16:32 |
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Articles in Press |
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2018-04-23 16:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-05-10 08:54 |
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Publish the Manuscript Online |
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2018-05-11 10:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
New therapeutic options opened by the molecular classification of gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu and Carmen Cristina Diaconu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mihaela Chivu-Economescu, PhD, Senior Researcher, Department of Cellular and Molecular Pathology, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest 030304, Romania. mihaela.economescu@virology.ro |
| Key Words |
Gastric cancer; Molecular classification; Immunotherapy; Targeted therapy; Clinical trials |
| Core Tip |
A new molecular classification of gastric cancer (GC) became available after publication of three landmark studies: The Cancer Genome Atlas, “Singapore-Duke” study, and Asian Cancer Research Group, allowing patient selection for specific targeted therapy. The Epstein-Barr virus positive, microsatellite stable TP53-active or microsatellite-unstable tumors subtypes presents tumour infiltrating patterns with overexpression of PD-1, PD-L1, PDL-2. Preliminary data show high response rate to immunotherapy and open new avenues to gene therapy. Currently effective therapies for diffuse GC are lacking. Mutations in e-cadherin and Ras homolog family member A genes, or Claudin-18-ARHGAP6/26 fusions may be exploited as therapeutic targets. The only targeted therapies approved so far for chromosomal instability and microsatellite stable TP53-inactive subtypes of GC are trastuzumab and ramucirumab (HER2 and VEGFR2 inhibitors). |
| Publish Date |
2018-05-11 10:51 |
| Citation |
Chivu-Economescu M, Matei L, Necula LG, Dragu DL, Bleotu C, Diaconu CC. New therapeutic options opened by the molecular classification of gastric cancer. World J Gastroenterol 2018; 24(18): 1942-1961 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i18/1942.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i18.1942 |
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