Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	38818
Country	Germany

Received	2018-03-17 08:00
Peer-Review Started	2018-03-17 13:36
To Make the First Decision	2018-04-19 02:33
Return for Revision	2018-04-24 07:41
Revised	2018-05-22 08:56
Second Decision	2018-06-12 08:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-06-13 22:11
Articles in Press	2018-06-13 22:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-12 09:17
Publish the Manuscript Online	2018-09-17 06:25

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Proposed approach to the challenging management of progressive gastroesophageal reflux disease
Manuscript Source	Unsolicited Manuscript
All Author List	Joachim Labenz, Parakrama T Chandrasoma, Laura J Knapp and Tom R DeMeester
ORCID	Author(s) ORCID Number Joachim Labenz http://orcid.org/0000-0002-6010-7841 Parakrama T Chandrasoma http://orcid.org/0000-0002-2168-9287 Laura J Knapp http://orcid.org/0000-0001-8811-8051 Tom R DeMeester http://orcid.org/0000-0002-2018-5773
Funding Agency and Grant Number
Corresponding Author	Joachim Labenz, MD, Doctor, Doctor, Professor, Internal Medicine, Diakonie Klinikum, Jung-Stilling Hospital, 40 Wichernstraße, Siegen 57074, Germany. joachim.labenz@diakonie-sw.de
Key Words	Barrett’s esophagus; Gastroesophageal reflux disease; Endoscopy; Progression; Treatment
Core Tip	A review of the literature on gastroesophageal reflux disease (GERD) progression and the associated physiological and pathological changes was performed. Current evidence shows that GERD can progress; however, patients at risk of progression may not be identified early enough for it to be prevented. We propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future progression. This will allow earlier intervention, aimed at preventing Barrett’s esophagus.
Publish Date	2018-09-17 06:25
Citation	Labenz J, Chandrasoma PT, Knapp LJ, DeMeester TR. Proposed approach to the challenging management of progressive gastroesophageal reflux disease. World J Gastrointest Endosc 2018; 10(9): 175-183
URL	http://www.wjgnet.com/1948-5190/full/v10/i9/175.htm
DOI	http://dx.doi.org/10.4253/wjge.v10.i9.175

Full Article (PDF)	WJGE-9-175.pdf
Full Article (Word)	WJGE-9-175.doc
Manuscript File	38818-Review.docx
Answering Reviewers	38818-Answering reviewers.pdf
Audio Core Tip	38818-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	38818-Conflict-of-interest statement.pdf
Copyright License Agreement	38818-Copyright license agreement.pdf
Peer-review Report	38818-Peer-review(s).pdf
Scientific Misconduct Check	38818-Scientific misconduct check.pdf
Scientific Editor Work List	38818-Scientific editor work list.pdf