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Articles Published Processes
6/26/2018 12:26:34 AM | Browse: 754 | Download: 969
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Received |
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2018-03-21 06:01 |
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Peer-Review Started |
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2018-03-21 08:27 |
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To Make the First Decision |
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2018-04-19 00:28 |
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Return for Revision |
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2018-04-24 07:50 |
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Revised |
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2018-04-30 14:41 |
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Second Decision |
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2018-05-24 08:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-05-26 14:43 |
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Articles in Press |
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2018-05-26 14:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-06-04 00:56 |
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Typeset the Manuscript |
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2018-06-25 07:05 |
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Publish the Manuscript Online |
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2018-06-26 00:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Tumor heterogeneity of gastric cancer: From the perspective of tumor-initiating cell
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jian-Peng Gao, Wei Xu, Wen-Tao Liu, Min Yan and Zheng-Gang Zhu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Jiao Tong University Medical Engineering Cross Research Fund |
YG2014MS59 |
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| Corresponding Author |
Wen-Tao Liu, MD, PhD, Associate Professor, Surgeon, Surgical Oncologist, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, 197 Ruijin Road II, Shanghai 200025, China. wt_mygod@163.com |
| Key Words |
Gastric cancer; Tumor heterogeneity; Tumor-initiating cell |
| Core Tip |
Gastric cancer (GC) remains a severe malignancy with high incidence and mortality rates. One major underlying mechanism of GC rapid progression, extensive spreading, and chemoresistance is tumor heterogeneity could be explained by the gastric tumor-initiating cell (GATIC). Since the initial identification of putative GATICs in 2007, substantial studies have been performed to investigate various aspects of GATICs. Here, we systemically discuss the tumor heterogeneity of GC from the view of GATICs by reviewing studies on the identification and validation of GATICs, origination of GATICs, plasticity of GATICs and its underlying mechanism, and current status of chemotherapeutic agents targeting GATICs. |
| Publish Date |
2018-06-26 00:26 |
| Citation |
Gao JP, Xu W, Liu WT, Yan M, Zhu ZG. Tumor heterogeneity of gastric cancer: From the perspective of tumor-initiating cell. World J Gastroenterol 2018; 24(24): 2567-2581 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i24/2567.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i24.2567 |
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