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Articles Published Processes
8/16/2018 11:54:24 AM | Browse: 975 | Download: 1522
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Received |
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2018-03-21 09:23 |
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Peer-Review Started |
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2018-03-21 09:34 |
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To Make the First Decision |
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2018-04-13 03:19 |
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Return for Revision |
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2018-04-18 10:35 |
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Revised |
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2018-04-23 13:37 |
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Second Decision |
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2018-05-11 10:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-05-13 16:14 |
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Articles in Press |
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2018-05-13 16:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-06-21 00:15 |
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Typeset the Manuscript |
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2018-08-14 13:14 |
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Publish the Manuscript Online |
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2018-08-16 11:54 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Must Peutz-Jeghers syndrome patients have the LKB1/STK11 gene mutation? A case report and review of the literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Fu-Xiao Duan, Guo-Li Gu, Hai-Rui Yang, Peng-Fei Yu and Zhi Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major Projects of Chinese PLA “13th Five-Year Plan” Logistics Research Subject |
AKJ15J003 |
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| Corresponding Author |
Guo-Li Gu, MD, MSc, Assistant Professor, Doctor, Doctor, Department of General Surgery, Air Force General Hospital of Chinese PLA, No.30, Fucheng Road, Haidian District, Beijing 100142, China. kzggl@163.com |
| Key Words |
Peutz-Jeghers syndrome; Gastrointestinal polyps; High-throughput sequencing; LKB1/STK11; APC; MSH6; Hamartoma |
| Core Tip |
The germline mutation of LKB1/STK11 gene on chromosome 19p13.3 is considered to be the hereditary cause of Peutz-Jeghers syndrome (PJS). We report a male PJS patient, who had typical manifestations and a definite family history, and but did not have LKB1/STK11 gene mutation. By means of high-throughput sequencing technology, only mutations in APC gene (c.6662T > C: p.Met2221Thr) and MSH6 gene (c.3488A > T: p.Glu1163Val) were detected in this case. This study suggests that some other genetic disorders may cause PJS besides LKB1/STK11 gene mutation. |
| Publish Date |
2018-08-16 11:54 |
| Citation |
Duan FX, Gu GL, Yang HR, Yu PF, Zhang Z. Must Peutz-Jeghers syndrome patients have the LKB1/STK11 gene mutation? A case report and review of the literature. World J Clin Cases 2018; 6(8): 224-232 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i8/224.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i8.224 |
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