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Articles Published Processes
6/15/2018 9:13:16 AM | Browse: 1086 | Download: 1893
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Received |
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2018-03-23 00:39 |
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Peer-Review Started |
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2018-03-23 03:56 |
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To Make the First Decision |
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2018-04-03 00:56 |
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Return for Revision |
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2018-04-10 11:50 |
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Revised |
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2018-04-17 17:09 |
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Second Decision |
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2018-05-17 08:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-05-18 01:33 |
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Articles in Press |
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2018-05-18 01:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-05-27 17:42 |
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Typeset the Manuscript |
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2018-06-13 08:42 |
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Publish the Manuscript Online |
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2018-06-15 09:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ben-Gang Wang, Qian Xu, Zhi Lv, Xin-Xin Fang, Han-Xi Ding, Jing Wen and Yuan Yuan |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province in China |
20170541001 |
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| Corresponding Author |
Yuan Yuan, MD, PhD, Professor, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No.155 NanjingBei Street, Heping District, Shenyang 110001, Liaoning Province, China. yuanyuan@cmu.edu.cn |
| Key Words |
Hepatocellular cancer; Single nucleotide polymorphism; Long non-coding RNA; Risk; Prognosis |
| Core Tip |
We aim to evaluate the association of twelve tag single nucleotide polymorphisms (tagSNPs) in three onco-lncRNA genes (HOTTIP, CCAT2, MALAT1) with the risk and prognosis of hepatocellular cancer (HCC). Twelve tagSNPs covering the three onco-lncRNAs were genotyped by the KASP method in a total of 1338 samples. We found three SNPs in HOTTIP, one promoter SNP in MALAT1 and one haplotype of HOTTIP gene were associated with HCC risk. In addition, HOTTIP rs3807598 variant genotype showed significantly longer survival time in hepatitis B virus (HBV) negative subgroup, and MALAT1 rs591291 showed significantly better prognosis in female and HBV negative subgroups. |
| Publish Date |
2018-06-15 09:13 |
| Citation |
Wang BG, Xu Q, Lv Z, Fang XX, Ding HX, Wen J, Yuan Y. Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study. World J Gastroenterol 2018; 24(23): 2482-2490 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i23/2482.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i23.2482 |
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