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Articles Published Processes
5/6/2018 1:12:00 PM | Browse: 1086 | Download: 1618
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Received |
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2018-03-21 06:22 |
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Peer-Review Started |
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2018-03-21 07:04 |
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To Make the First Decision |
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2018-03-29 00:54 |
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Return for Revision |
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2018-03-30 02:41 |
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Revised |
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2018-04-01 09:51 |
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Second Decision |
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2018-04-13 09:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-04-15 23:10 |
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Articles in Press |
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2018-04-15 23:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-05-04 09:58 |
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Publish the Manuscript Online |
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2018-05-06 13:12 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-naïve chronic hepatitis B: A case report and review of the literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Woo Hee Cho, Hyun Jae Lee, Ki Bae Bang, Seok Bae Kim and Il Han Song |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Seok Bae Kim, MD, Professor, Department of Internal Medicine, Dankook University College of Medicine, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, South Korea. 11961019@dankook.ac.kr |
| Key Words |
Chronic hepatitis B; Tenofovir; Resistance; Mutation |
| Core Tip |
The results of many clinical longitudinal studies of Tenofovir disoproxil fumarate (TDF) treatment have demonstrated no development of resistance until now. Recently, a few cases of resistance to TDF have been reported. However, the mutation site had not been clearly revealed and confirmed because of the rarity of resistant cases. In the present case, TDF resistance developed following the complete suppression of HBV DNA in a treatment-naïve patient. We detected 9 mutation sites, including some that have been unknown until now. We believe that the present study is helpful in revealing the exact mutation sites associated with TDF resistance. |
| Publish Date |
2018-05-06 13:12 |
| Citation |
Cho WH, Lee HJ, Bang KB, Kim SB, Song IH. Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-naïve chronic hepatitis B: A case report and review of the literature. World J Gastroenterol 2018; 24(17): 1919-1924 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i17/1919.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i17.1919 |
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