Publication Name	World Journal of Gastroenterology
Manuscript ID	38881
Country	South Korea

Received	2018-03-21 06:22
Peer-Review Started	2018-03-21 07:04
To Make the First Decision	2018-03-29 00:54
Return for Revision	2018-03-30 02:41
Revised	2018-04-01 09:51
Second Decision	2018-04-13 09:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-04-15 23:10
Articles in Press	2018-04-15 23:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-05-04 09:58
Publish the Manuscript Online	2018-05-06 13:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-naïve chronic hepatitis B: A case report and review of the literature
Manuscript Source	Unsolicited Manuscript
All Author List	Woo Hee Cho, Hyun Jae Lee, Ki Bae Bang, Seok Bae Kim and Il Han Song
ORCID	Author(s) ORCID Number Woo Hee Cho http://orcid.org/0000-0003-2246-6517 Hyun Jae Lee http://orcid.org/0000-0002-3983-4518 Ki Bae Bang http://orcid.org/0000-0002-9961-9318 Seok Bae Kim http://orcid.org/0000-0002-6857-9624 Il Han Song http://orcid.org/0000-0003-3975-6342
Funding Agency and Grant Number
Corresponding Author	Seok Bae Kim, MD, Professor, Department of Internal Medicine, Dankook University College of Medicine, 119 Dandae-ro, Dongnam-gu, Cheonan 31116, South Korea. 11961019@dankook.ac.kr
Key Words	Chronic hepatitis B; Tenofovir; Resistance; Mutation
Core Tip	The results of many clinical longitudinal studies of Tenofovir disoproxil fumarate (TDF) treatment have demonstrated no development of resistance until now. Recently, a few cases of resistance to TDF have been reported. However, the mutation site had not been clearly revealed and confirmed because of the rarity of resistant cases. In the present case, TDF resistance developed following the complete suppression of HBV DNA in a treatment-naïve patient. We detected 9 mutation sites, including some that have been unknown until now. We believe that the present study is helpful in revealing the exact mutation sites associated with TDF resistance.
Publish Date	2018-05-06 13:12
Citation	Cho WH, Lee HJ, Bang KB, Kim SB, Song IH. Development of tenofovir disoproxil fumarate resistance after complete viral suppression in a patient with treatment-naïve chronic hepatitis B: A case report and review of the literature. World J Gastroenterol 2018; 24(17): 1919-1924
URL	http://www.wjgnet.com/1007-9327/full/v24/i17/1919.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i17.1919

Full Article (PDF)	WJG-24-1919.pdf
CARE Checklist–2016	38881-CARE checklist .pdf
Manuscript File	38881-Review.docx
Answering Reviewers	38881-Answering reviewers.pdf
Audio Core Tip	38881-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	38881-Conflict-of-interest statement.pdf
Copyright License Agreement	38881-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	38881-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	38881-Non-Native Speakers of English Editing Certificate.pdf
Peer-review Report	38881-Peer-review(s).pdf
Scientific Misconduct Check	38881-Scientific misconduct check.pdf
Scientific Editor Work List	38881-Scientific editor work list.pdf