Publication Name	World Journal of Gastroenterology
Manuscript ID	38899
Country	Sri Lanka

Received	2018-03-26 11:42
Peer-Review Started	2018-03-27 06:38
To Make the First Decision	2018-04-11 07:27
Return for Revision	2018-04-13 06:42
Revised	2018-04-26 09:47
Second Decision	2018-05-10 09:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-05-11 04:52
Articles in Press	2018-05-11 04:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-01 04:06
Publish the Manuscript Online	2018-06-04 07:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Irritable bowel syndrome in children: Current knowledge, challenges and opportunities
Manuscript Source	Invited Manuscript
All Author List	Niranga Manjuri Devanarayana and Shaman Rajindrajith
ORCID	Author(s) ORCID Number Niranga Manjuri Devanarayana http://orcid.org/0000-0002-2988-110X Shaman Rajindrajith http://orcid.org/0000-0003-1379-5052
Funding Agency and Grant Number
Corresponding Author	Niranga Manjuri Devanarayana, MBBS, MD, PhD, Professor, Department of Physiology, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama 111010, Sri Lanka. niranga1230@lycos.com
Key Words	Abdominal pain; Functional gastrointestinal disorder; Irritable bowel syndrome; Management; Microbiota; Patho-physiology; Post-infectious
Core Tip	Even though irritable bowel syndrome (IBS) is a common worldwide pediatric problem, little is known of its exact patho-physiology and management. Therefore, a large number of children are suffering from its intestinal and extra-intestinal symptoms. Novel research using new advanced technologies based on proposed top-down and bottom-up models of patho-physiology and treatment trials focusing on multiple combined interventions are likely to be more beneficial in understating and treating pediatric IBS. In addition, the time has come to explore possible prevention strategies for this problem.
Publish Date	2018-06-04 07:22
Citation	Devanarayana NM, Rajindrajith S. Irritable bowel syndrome in children: Current knowledge, challenges and opportunities. World J Gastroenterol 2018; 24(21): 2211-2235
URL	http://www.wjgnet.com/1007-9327/full/v24/i21/2211.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i21.2211

Full Article (PDF)	WJG-24-2211.pdf
Full Article (Word)	WJG-24-2211.doc
Manuscript File	38899-Review.docx
Answering Reviewers	38899-Answering-Reviewers-revision.docx
Audio Core Tip	38899-Audio core tip.wav
Conflict-of-Interest Disclosure Form	38899-Conflict-of-interest statement.pdf
Copyright License Agreement	38899-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	38899-Language certificate.pdf
Peer-review Report	38899-Peer-review(s).pdf
Scientific Misconduct Check	38899-Scientific misconduct check.pdf
Scientific Editor Work List	38899-Scientific editor work list.pdf