Publication Name	World Journal of Diabetes
Manuscript ID	3890
Country	Türkiye

Received	2013-05-31 08:14
Peer-Review Started	2013-05-31 11:16
To Make the First Decision	2013-07-05 18:39
Return for Revision	2013-07-15 22:34
Revised
Second Decision	2013-08-29 07:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-29 09:55
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-09-06 04:27
Typeset the Manuscript	2013-09-22 10:29
Publish the Manuscript Online	2013-10-16 11:30

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Autobiography
Article Title	High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity?
Manuscript Source	Invited Manuscript
All Author List	Altan Onat, Mesut Aydın, Günay Can, Bayram Köroğlu, Ahmet Karagöz and Servet Altay
Funding Agency and Grant Number	Funding Agency Grant Number Turkish Society of Cardiology
Corresponding Author	Altan Onat, Professor, Department of Cardiology, Cerrahpaşa Medical Faculty, Istanbul University, Nisbetiye cad. 59/24, 34335 Etiler, Istanbul, Turkey. alt_onat@yahoo.com.tr
Key Words	Adiponectin; Antioxidative function; Coronary heart disease; Creatinine; Type-2 diabetes; Hypertension
Core Tip	The issue of whether serum adiponectin protects against cardiometabolic risk in people prone to metabolic syndrome was studied in 1224 Turkish adults at a mean of 3.8 years’ follow-up. High adiponectin levels were surprisingly positively associated independently with serum creatinine in women and further failed to protect against the development of hypertension in both sexes. In multivariable adjusted Cox proportional hazards regression analyses, protection against type-2 diabetes was apparent, but women were not protected against incident coronary heart disease by high serum adiponectin. Involvement of circulating adiponectin in autoimmune complex with loss of mainly antioxidative properties may be underlying.
Publish Date	2013-10-16 11:30
Citation	Onat A, Ayd?n M, Can G, K?ro?lu B, Karag?z A, Altay S. High adiponectin levels fail to protect against the risk of hypertension and, in women, against coronary disease: involvement in autoimmunity? World J Diabetes 2013; 4(5): 219-225
URL	http://www.wjgnet.com/1948-9358/full/v4/i5/219.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i5.219

Full Article (PDF)	WJD-4-219.pdf
Manuscript File	3890-Review.doc
Answering Reviewers	3890-Answering reviewers.pdf
Copyright License Agreement	3890-Copyright assignment.pdf
Peer-review Report	3890-Peer review(s).pdf
Scientific Editor Work List	3890-Scientific editor work list.doc