Publication Name	World Journal of Gastroenterology
Manuscript ID	38918
Country	Spain

Received	2018-03-25 06:02
Peer-Review Started	2018-03-25 11:50
To Make the First Decision	2018-04-27 02:02
Return for Revision	2018-04-27 03:35
Revised	2018-05-04 07:50
Second Decision	2018-06-08 08:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-06-09 04:32
Articles in Press	2018-06-09 04:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-06-25 07:05
Publish the Manuscript Online	2018-06-26 00:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Review
Article Title	Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Esther Llop, Pedro E Guerrero, Adrià Duran, Sílvia Barrabés, Anna Massaguer, María José Ferri, Maite Albiol-Quer, Rafael de Llorens and Rosa Peracaula
ORCID	Author(s) ORCID Number Esther Llop http://orcid.org/0000-0003-0929-4888 Pedro E Guerrero http://orcid.org/0000-0003-2612-9235 Adrià Duran http://orcid.org/0000-0002-4180-4369 Sílvia Barrabés http://orcid.org/0000-0001-7004-0057 Anna Massaguer http://orcid.org/0000-0003-1312-593X María José Ferri http://orcid.org/0000-0002-2885-7175 Maite Albiol-Quer http://orcid.org/0000-0002-4267-7410 Rafael de Llorens http://orcid.org/0000-0003-2260-2873 Rosa Peracaula http://orcid.org/0000-0003-3513-524X
Funding Agency and Grant Number	Funding Agency Grant Number Spanish Ministry of Economy and Competitivity BIO 2015-66356-R Generalitat de Catalunya Grant 2017SGR673
Corresponding Author	Rosa Peracaula, PhD, Associate Professor, Department of Biology, Biochemistry and Molecular Biology Unit, University of Girona, C/Maria Aurèlia Capmany 40, Girona 17003, Spain. rosa.peracaula@udg.edu
Key Words	Pancreatic cancer; Aberrant glycosylation; Glycoproteins; Biomarkers; Diagnosis
Core Tip	There is an urgent need to find new biomarkers for pancreatic cancer (PaC) diagnosis. The review focuses on the field of glycoproteomics and describes serum glycoproteins that have been identified up to date as po­tential biomarkers and their limitations basically due to the fact that they are neither pancreatic specific nor cancer specific. The review proposes new glycoprotein candidates that have been described to be overexpressed in PaC tissues and that are secreted into serum. The combination of the candidate protein levels and their glycan moieties, which could be altered in cancer, could improve their potential as PaC biomarkers.
Publish Date	2018-06-26 00:26
Citation	Llop E, Guerrero PE, Duran A, Barrabés S, Massaguer A, Ferri MJ, Albiol-Quer M, de Llorens R, Peracaula R. Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma. World J Gastroenterol 2018; 24(24): 2537-2554
URL	http://www.wjgnet.com/1007-9327/full/v24/i24/2537.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i24.2537

Full Article (PDF)	WJG-24-2537.pdf
Manuscript File	38918-Review.docx
Answering Reviewers	38918-Answering reviewers.pdf
Audio Core Tip	38918-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	38918-Conflict-of-interest statement.pdf
Copyright License Agreement	38918-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	38918-Grant application form(s).pdf
Peer-review Report	38918-Peer-review(s).pdf
Scientific Misconduct Check	38918-Scientific misconduct check.pdf
Scientific Editor Work List	38918-Scientific editor work list.pdf