Publication Name	World Journal of Clinical Cases
Manuscript ID	38942
Country	China

Received	2018-04-03 00:45
Peer-Review Started	2018-04-03 09:00
To Make the First Decision	2018-06-06 07:37
Return for Revision	2018-06-08 01:29
Revised	2018-07-31 12:19
Second Decision	2018-08-06 09:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-07 05:46
Articles in Press	2018-08-07 05:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-08-30 12:11
Publish the Manuscript Online	2018-09-07 01:56

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Hepatitis B virus-persistent infection and innate immunity defect: Cell-related or virus-related?
Manuscript Source	Invited Manuscript
All Author List	Jian Tang, Zhen-Yu Wu, Rong-Juan Dai, Jing Ma and Guo-Zhong Gong
ORCID	Author(s) ORCID Number Jian Tang http://orcid.org/0000-0001-5345-3028 Zhen-Yu Wu http://orcid.org/0000-0003-4478-0734 Rong-Juan Dai http://orcid.org/0000-0001-9455-8328 Jing Ma http://orcid.org/0000-0001-8925-7686 Guo-Zhong Gong http://orcid.org/0000-0002-1824-1625
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81500455
Corresponding Author	Guo-Zhong Gong, PhD, Professor, Department of Infectious Disease, the Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. gongguozhong@csu.edu.cn
Key Words	Hepatitis B virus; Innate immunity; Immune evasion; Pattern recognition receptor; Toll-like receptor; Natural killer cells; Kupffer cells; Dendritic cells
Core Tip	This review covers the following core concepts of hepatitis B virus (HBV) persistence, according to the most up-to-date literature: Hepatocytes lack immune responsiveness to HBV; Innate immune cells display weak responses at the early stages of HBV infection; HBV impairs functions of innate immune cells and select signaling pathways to evade immune recognition and response.
Publish Date	2018-09-07 01:56
Citation	Tang J, Wu ZY, Dai RJ, Ma J, Gong GZ. Hepatitis B virus-persistent infection and innate immunity defect: Cell-related or virus-related? World J Clin Cases 2018; 6(9): 233-241
URL	http://www.wjgnet.com/2307-8960/full/v6/i9/233.htm
DOI	http://dx.doi.org/10.12998/wjcc.v6.i9.233

Full Article (PDF)	WJCC-6-233.pdf
Full Article (Word)	WJCC-6-233.doc
Manuscript File	38942-Review.docx
Answering Reviewers	38942-Answering reviewers.pdf
Audio Core Tip	38942-Audio core tip.wma
Conflict-of-Interest Disclosure Form	38942-Conflict-of-interest statement.pdf
Copyright License Agreement	38942-Copyright license agreement.PDF
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	38942-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	38942-Language certificate.pdf
Peer-review Report	38942-Peer-review(s).pdf
Scientific Misconduct Check	38942-Scientific misconduct check.pdf
Scientific Editor Work List	38942-Scientific editor work list.pdf