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Articles Published Processes
10/26/2018 2:42:07 PM | Browse: 570 | Download: 678
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Received |
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2018-03-28 00:28 |
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Peer-Review Started |
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2018-03-28 09:32 |
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To Make the First Decision |
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2018-05-02 03:44 |
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Return for Revision |
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2018-05-03 07:45 |
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Revised |
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2018-08-11 20:52 |
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Second Decision |
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2018-08-22 06:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2018-08-27 00:46 |
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Articles in Press |
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2018-08-27 00:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-09-09 01:48 |
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Typeset the Manuscript |
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2018-10-26 00:36 |
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Publish the Manuscript Online |
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2018-10-26 14:42 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Undiscovered pathology of transient scaffolding remains a driver of failures in clinical trials
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alexander N Kharlamov |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Alexander N Kharlamov, MD, Academic Research, Doctor, Lecturer, Department of Interventional Cardiovascular Biomedicine, De Haar Research Foundation, Handelsplein 15, Rotterdam 3071PR, Netherlands. akharlamov@dhrfpro.com |
| Key Words |
Bioresorbable scaffold; Device thrombosis; Clinical outcomes; Statistics; Intravascular imaging; Arterial remodeling; Transient scaffolding |
| Core Tip |
The high rates of target lesion failure and device thrombosis in randomized controlled trials caused confusion in the international interventional community with a decline of the technology in routine practice. The provided statistical analysis confirms the underpowered design of some clinical studies and meta-analyses of bioresorbable scaffolds. The misunderstanding of the pathobiology of the transient scaffolding drives the failures of the clinical trials. More bench studies of the vascular response are required to verify the leading mechanism of the device failure. Several next-generation scaffolds including multifunctional electronic scaffold grant cardiology with a huge promise to make this technology great again.V |
| Publish Date |
2018-10-26 14:42 |
| Citation |
Kharlamov AN. Undiscovered pathology of transient scaffolding remains a driver of failures in clinical trials. World J Cardiol 2018; 10(10): 165-186 |
| URL |
http://www.wjgnet.com/1949-8462/full/v10/i10/165.htm |
| DOI |
http://dx.doi.org/10.4330/wjc.v10.i10.165 |
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