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Articles Published Processes
9/7/2018 6:15:25 AM | Browse: 1026 | Download: 1195
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Received |
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2018-04-24 07:57 |
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Peer-Review Started |
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2018-04-24 17:24 |
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To Make the First Decision |
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2018-06-08 03:05 |
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Return for Revision |
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2018-06-08 07:34 |
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Revised |
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2018-06-14 15:55 |
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Second Decision |
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2018-06-26 12:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-06-27 23:46 |
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Articles in Press |
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2018-06-27 23:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-09-06 04:09 |
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Publish the Manuscript Online |
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2018-09-07 06:15 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Petra E de Ruiter, Yashna Gadjradj, Robert de Knegt, Herold J Metselaar, Jan NM IJzermans and Luc JW van der Laan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Luc JW van der Laan, MSc, PhD, Associate Professor, Laboratory of Experimental Transplantation and Intestinal Surgery, Department of Surgery, Erasmus MC-University Medical Center, Room Na1006, Wytemaweg 80, Rotterdam CN 3015, Netherlands. l.vanderlaan@erasmusmc.nl |
| Key Words |
Immunosuppressant; Hepatitis C; Daclatasvir; Asunaprevir; Liver; Transplantation |
| Core Tip |
Since 2013, several new generation direct acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV), including daclatasvir (DCV) and asunaprevir (ASV). Although a few reports investigated the effectivity of DAAs after liver transplantation, the effects of specific immunosuppressants on the antiviral efficacy remain largely unknown. We investigated the effect of the immunosuppressants on the antiviral action of DCV and ASV in two in vitro models for HCV. We observed that none of the immunosuppressants negatively affected the antiviral activity of these DAAs, and that mycophenolic acid has an additive effect on their antiviral action. |
| Publish Date |
2018-09-07 06:15 |
| Citation |
de Ruiter PE, Gadjradj Y, de Knegt R, Metselaar HJ, Ijzermans JNM, van der Laan LJW. Interaction of immunosuppressants with HCV antivirals daclatasvir and asunaprevir: combined effects with mycophenolic acid. World J Transplant 2018; 8(5): 156-166 |
| URL |
http://www.wjgnet.com/2220-3230/full/v8/i5/156.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v8.i5.156 |
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