| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Arnau Panisello Roselló, Alexandre Lopez, Emma Folch-Puy, Teresa Carbonell, Anabela Rolo, Carlos M Palmeira, Marc Net Abraham and Joan Rosello-Catafau |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Joan Rosello-Catafau, DPhil, N/A, Adjunct Professor, Doctor, Doctor, N/A, N/A, Hepatic Ischemia-Reperfusion unit, Instituto de investigaciones biomédicas de Barcelona., C/Roselló 161, Barcelona 08036, Catalunya, Spain. jrcbam@iibb.csic.es |
| Key Words |
Aldehyde dehydrogenase 2; 4-hydroxy-2-nonenal autophagy; Apoptosis; Ischemia reperfusion injury; Preconditioning |
| Core Tip |
Aldehyde dehydrogenase 2 (ALDH2) plays a crucial role not only in liver ethanol metabolism but also in diverse pathophysiological dysfunctions including cardiovascular diseases, stroke, diabetes, neuro-degenerative dysfunctions, and aging. Its involvement has recently been identified in ischemia reperfusion injury (IRI). The present study provides an updated review of the literature on the role of ALDH2 in ischemia-reperfusion injury and its activation in different organs (heart, brain, kidney, intestine, etc) focusing especially on its possible use as a potential therapeutic target for preventing IRI associated with organ transplantation. |
| Publish Date |
2018-07-19 07:04 |
| Citation |
Panisello-Roselló A, Lopez A, Folch-Puy E, Carbonell T, Rolo A, Palmeira C, Adam R, Net M, Roselló-Catafau J. Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update. World J Gastroenterol 2018; 24(27): 2984-2994 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i27/2984.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i27.2984 |
