Publication Name	World Journal of Gastroenterology
Manuscript ID	3925
Country	China

Received	2013-06-02 22:18
Peer-Review Started	2013-06-02 22:32
To Make the First Decision	2013-07-05 18:18
Return for Revision	2013-07-15 23:03
Revised	2013-08-15 12:21
Second Decision	2013-09-29 13:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-29 22:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-20 10:39
Typeset the Manuscript	2013-12-05 16:09
Publish the Manuscript Online	2013-12-18 10:00

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clinicopathological and biological significance of cripto overexpression in human colon cancer
Manuscript Source	Invited Manuscript
All Author List	Peng-Cheng Jiang, Ling Zhu, Yu Fan and Hao-Liang Zhao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Fund 81250035 Jiangsu Province of 333 Engineering talent fund RA2012103 Zhenjiang City Social Development Fund SH2011031 Zhenjiang City Social Development Fund SH2011034
Corresponding Author	Hao-Liang Zhao, Professor, Department of General Surgery, Affiliated First Hospital of Shanxi Medical University, The liberation of South, Taiyuan 030001, Shanxi Province, China. 18952819981@163.com
Key Words	Colon cancer; Invasion; Metastasis; Cripto; Small interfering RNA; Matrix metalloproteinases
Core Tip	To assess the clinicopathologic and biological significance of cripto as a novel target for colon cancer gene therapy, pathological and in vitro studies were carried out. Cripto was significantly overexpressed in primary colon cancer and metastatic lymph nodes. In vitro studies found that cripto siRNA resulted in a significant reduction in colony formation in soft agar and in the migration and invasion abilities of colon cancer cells. Furthermore, cripto siRNA led to an inhibition of MMP-7 and MMP-9. These results suggest that the cripto gene be useful for devising novel preventive and therapeutic strategies for colon cancer.
Publish Date	2013-12-18 10:00
Citation	Jiang PC, Zhu L, Fan Y, Zhao HL. Clinicopathological and biological significance of cripto overexpression in human colon cancer. World J Gastroenterol 2013; 19(46): 8630-8637
URL	http://www.wjgnet.com/1007-9327/full/v19/i46/8630.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i46.8630

Full Article (PDF)	WJG-19-8630.pdf
Manuscript File	3925-Review.doc
Answering Reviewers	3925-Answering reviewers.pdf
Copyright License Agreement	3925-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3925-Language certificate.pdf
Peer-review Report	3925-Peer review(s).pdf
Scientific Editor Work List	3925-Scientific editor work list.doc