Publication Name	World Journal of Clinical Oncology
Manuscript ID	39252
Country	India

Received	2018-06-16 14:21
Peer-Review Started	2018-06-17 12:51
To Make the First Decision	2018-07-19 07:45
Return for Revision	2018-07-23 03:07
Revised	2018-08-24 09:02
Second Decision	2018-11-01 02:25
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-11-04 20:25
Articles in Press	2018-11-04 20:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-12-17 03:15
Publish the Manuscript Online	2018-12-21 01:32

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model
Manuscript Source	Invited Manuscript
All Author List	Himani Garg, Rohit Singh Hada, Jagdish C Gupta, G P Talwar and Shweta Dubey
ORCID	Author(s) ORCID Number Himani Garg http://orcid.org/0000-0002-4672-8289 Rohit Singh Hada http://orcid.org/0000-0002-3236-3047 Jagdish C Gupta http://orcid.org/0000-0002-9456-0097 G P Talwar http://orcid.org/0000-0002-3421-1303 Shweta Dubey http://orcid.org/0000-0002-0457-9692
Funding Agency and Grant Number	Funding Agency Grant Number Science and Engineering Research Board under the Department of Science and Technology, Govt of India SR/FT/LS-75/2012 Science and Engineering Research Board under the Department of Science and Technology, Govt of India SB/SO/HS/062/2013
Corresponding Author	Shweta Dubey, PhD, Associate Professor, Amity Institute of Virology and Immunology, Amity University Uttar Pradesh, J-3 Block, Room No: LG21, Sector 125, Noida 201303, Uttar Pradesh, India. sdubey@amity.edu
Key Words	Immunotherapy; Survivin; Luteinizing hormone-releasing hormone fusion protein; Combination immunotherapy; Breast cancer
Core Tip	Targeting Survivin for treatment of cancer is an emerging trend in cancer immunotherapy. In this study we optimized the dose of recombinant full-length Survivin for tumor growth inhibition. Since luteinizing hormone-releasing hormone (LHRH) is also known to support breast cancer in case of premenopausal women, we combined recombinant LHRH fusion protein with Survivin and Mycobacterium indicus pranii and obtained a positive anti-tumor response. We report our results of using recombinant Survivin protein and LHRH fusion protein as potential vaccine antigens for immunotherapy of murine model of breast cancer which was developed by injecting 4T-1 mammary cell line in syngeneic Balb/c mice. Immunized mice challenged with syngeneic 4T-1 cells exhibited suppression of tumor growth and metastasis in lungs in comparison to control mice.
Publish Date	2018-12-21 01:32
Citation	Garg H, Hada RS, Gupta JC, Talwar GP, Dubey S. Combination immunotherapy with Survivin and luteinizing hormone-releasing hormone fusion protein in murine breast cancer model. World J Clin Oncol 2018; 9(8): 188-199
URL	https://www.wjgnet.com/2218-4333/full/v9/i8/188.htm
DOI	https://dx.doi.org/10.5306/wjco.v9.i8.188

Full Article (PDF)	WJCO-9-188.pdf
Full Article (Word)	WJCO-9-188.doc
The ARRIVE Guidelines	39252-The ARRIVE Guidelines.pdf
Manuscript File	39252-Review.docx
Answering Reviewers	39252-Answering reviewers.pdf
Audio Core Tip	39252-Audio core tip.mp3
Biostatistics Review Certificate	39252-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39252-Conflict-of-interest statement.pdf
Copyright License Agreement	39252-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39252-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	39252-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	39252-Institutional review board statement.pdf
Peer-review Report	39252-Peer-review(s).pdf
Scientific Misconduct Check	39252-Scientific misconduct check.pdf
Scientific Editor Work List	39252-Scientific editor work list.pdf