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9/12/2014 8:40:00 PM | Browse: 1054 | Download: 734
Publication Name World Journal of Gastroenterology
Manuscript ID 3929
Country/Territory Australia
Received
2013-06-02 22:36
Peer-Review Started
2013-06-04 14:38
To Make the First Decision
2013-06-24 10:19
Return for Revision
2013-07-01 14:00
Revised
2013-07-15 10:35
Second Decision
2013-08-20 12:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-08-20 13:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-09-22 17:37
Publish the Manuscript Online
2013-10-18 17:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Autobiography
Article Title Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells
Manuscript Source Invited Manuscript
All Author List Xiao-Jun Liu, Zhao-Feng Chen, Hai-Long Li, Ze-Nan Hu, Min Liu, Ai-Ping Tian, Da Zhao, Jing Wu, Yong-Ning Zhou and Liang Qiao
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Funding of China 81172366
Fundamental Research Funds for the Central Universities lzujbky-2012-224
Gansu Special Program for High Technology Research and Development 0912TCYA027
Corresponding Author Dr. Liang Qiao, MD, PhD, Storr Liver Unit, Westmead Millennium Institute, Western Clinical School of the Faculty of Medicine at Westmead Hospital, Westmead NSW 2145, Australia. liang.qiao@sydney.edu.au
Key Words Cyclooxygenase-2; E-cadherin; celecoxib; Prostaglandin E2; Gastric cancer
Core Tip Cyclooxygenase-2 (COX-2) plays an important role in transcriptional regulation of E-cadherin in gastric cancer and other malignancies. On the contrary, prostaglandin E2 (PGE2) promotes invasion of tumor cells through down-regulating the expression of E-cadherin. Our study has provided further evidence that COX-2 functions upstream of nuclear factor-?B in the regulation of Snail and E-cadherin in gastric cancer cells. Blockade of COX-2 activity or inhibition of PGE2 production may offer some benefit in the chemoprevention and treatment of gastric cancer.
Publish Date 2013-10-18 17:02
Citation Liu XJ, Chen ZF, Li HL, Hu ZN, Liu M, Tian AP, Zhao D, Wu J, Zhou YN, Qiao L. Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells. World J Gastroenterol 2013; 19(37): 6265-6271
URL http://www.wjgnet.com/1007-9327/full/v19/i37/6265.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i37.6265
Full Article (PDF) WJG-19-6265.pdf
Manuscript File 3929-Review.doc
Answering Reviewers 3929-Answering reviewers.pdf
Copyright License Agreement 3929-Copyright assignment.doc
Peer-review Report 3929-Peer review(s).pdf
Scientific Editor Work List 3929-Scientific editor work list.doc