Publication Name	World Journal of Gastroenterology
Manuscript ID	3929
Country	Australia

Received	2013-06-02 22:36
Peer-Review Started	2013-06-04 14:38
To Make the First Decision	2013-06-24 10:19
Return for Revision	2013-07-01 14:00
Revised	2013-07-15 10:35
Second Decision	2013-08-20 12:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-08-20 13:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-22 17:37
Publish the Manuscript Online	2013-10-18 17:02

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Autobiography
Article Title	Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells
Manuscript Source	Invited Manuscript
All Author List	Xiao-Jun Liu, Zhao-Feng Chen, Hai-Long Li, Ze-Nan Hu, Min Liu, Ai-Ping Tian, Da Zhao, Jing Wu, Yong-Ning Zhou and Liang Qiao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Funding of China 81172366 Fundamental Research Funds for the Central Universities lzujbky-2012-224 Gansu Special Program for High Technology Research and Development 0912TCYA027
Corresponding Author	Dr. Liang Qiao, MD, PhD, Storr Liver Unit, Westmead Millennium Institute, Western Clinical School of the Faculty of Medicine at Westmead Hospital, Westmead NSW 2145, Australia. liang.qiao@sydney.edu.au
Key Words	Cyclooxygenase-2; E-cadherin; celecoxib; Prostaglandin E2; Gastric cancer
Core Tip	Cyclooxygenase-2 (COX-2) plays an important role in transcriptional regulation of E-cadherin in gastric cancer and other malignancies. On the contrary, prostaglandin E2 (PGE2) promotes invasion of tumor cells through down-regulating the expression of E-cadherin. Our study has provided further evidence that COX-2 functions upstream of nuclear factor-?B in the regulation of Snail and E-cadherin in gastric cancer cells. Blockade of COX-2 activity or inhibition of PGE2 production may offer some benefit in the chemoprevention and treatment of gastric cancer.
Publish Date	2013-10-18 17:02
Citation	Liu XJ, Chen ZF, Li HL, Hu ZN, Liu M, Tian AP, Zhao D, Wu J, Zhou YN, Qiao L. Interaction between cyclooxygenase-2, Snail, and E-cadherin in gastric cancer cells. World J Gastroenterol 2013; 19(37): 6265-6271
URL	http://www.wjgnet.com/1007-9327/full/v19/i37/6265.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i37.6265

Full Article (PDF)	WJG-19-6265.pdf
Manuscript File	3929-Review.doc
Answering Reviewers	3929-Answering reviewers.pdf
Copyright License Agreement	3929-Copyright assignment.doc
Peer-review Report	3929-Peer review(s).pdf
Scientific Editor Work List	3929-Scientific editor work list.doc