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Publication Name World Journal of Diabetes
Manuscript ID 3933
Country/Territory Czech Republic
Received
2013-06-03 18:27
Peer-Review Started
2013-06-04 11:46
To Make the First Decision
2013-06-24 10:33
Return for Revision
2013-07-04 16:01
Revised
2013-08-15 03:37
Second Decision
2013-11-15 19:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-16 01:47
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2013-12-02 13:52
Typeset the Manuscript
2013-12-13 12:30
Publish the Manuscript Online
2013-12-20 16:49
ISSN 1948-9358 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Autobiography
Article Title Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers
Manuscript Source Invited Manuscript
All Author List Michal Krčma, Daniela Čechurová, Jitka Brožová, Zdeněk Jankovec, Silvie Lacigová, Michal Žourek and Zdeněk Rušavý
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Health, Czech Republic-Conceptual Development of Research Organization (Faculty Hospital in Pilsen-FNPl) 00669806
Corresponding Author Michal Krčma, MD, PhD, Diabetology Centre, 1st Department of Clinic Medicine, Teaching Hospital and Medical Faculty Charles University, Alej Svobody 80, 32300 Plzen, Czech Republic. krcmam@fnplzen.cz
Key Words Diabetes; Insulin; Laser Doppler flowmetry; Microcirculation
Core Tip Insulin mediated small vessel vasodilatation is a hot topic in microcirculation research. Our work describes skin microcirculation response to increasing insulinemia in the physiological and supraphysiological level. Simultaneous use of two laser Doppler flowmetry and transcutaneous oximetry was used for discriminating between total blood flow and perfusion of the nutritive bed. Both methods reveal increasing skin microcirculation perfusion due to insulin infusion with this effect rising non-linearly with increasing insulinemia.
Publish Date 2013-12-20 16:49
Citation Kr?ma M, ?echurová D, Bro?ová J, Jankovec Z, Lacigová S, ?ourek M, Ru?avy Z. Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers. World J Diabetes 2013; 4(6): 372-377 Available from: URL: http://www.wjgnet.com/1948-9358/full/v4/i6/372.htm DOI: http://dx.doi.org/10.4239/wjd.v4.i6.372
URL http://www.wjgnet.com/1948-9358/full/v4/i6/372.htm
DOI http://dx.doi.org/10.4239/wjd.v4.i6.372
Full Article (PDF) WJD-4-372.pdf
Full Article (Word) WJD-4-372.doc
Manuscript File 3933-Review.doc
Answering Reviewers 3933-Answering reviewers.pdf
Copyright License Agreement 3933-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 3933-Language certificate.pdf
Peer-review Report 3933-Peer reviewer(s).pdf
Scientific Editor Work List 3933-Scientific editor work list.doc