Publication Name	World Journal of Diabetes
Manuscript ID	3933
Country	Czech Republic

Received	2013-06-03 18:27
Peer-Review Started	2013-06-04 11:46
To Make the First Decision	2013-06-24 10:33
Return for Revision	2013-07-04 16:01
Revised	2013-08-15 03:37
Second Decision	2013-11-15 19:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 01:47
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-12-02 13:52
Typeset the Manuscript	2013-12-13 12:30
Publish the Manuscript Online	2013-12-20 16:49

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Autobiography
Article Title	Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers
Manuscript Source	Invited Manuscript
All Author List	Michal Krčma, Daniela Čechurová, Jitka Brožová, Zdeněk Jankovec, Silvie Lacigová, Michal Žourek and Zdeněk Rušavý
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health, Czech Republic-Conceptual Development of Research Organization (Faculty Hospital in Pilsen-FNPl) 00669806
Corresponding Author	Michal Krčma, MD, PhD, Diabetology Centre, 1st Department of Clinic Medicine, Teaching Hospital and Medical Faculty Charles University, Alej Svobody 80, 32300 Plzen, Czech Republic. krcmam@fnplzen.cz
Key Words	Diabetes; Insulin; Laser Doppler flowmetry; Microcirculation
Core Tip	Insulin mediated small vessel vasodilatation is a hot topic in microcirculation research. Our work describes skin microcirculation response to increasing insulinemia in the physiological and supraphysiological level. Simultaneous use of two laser Doppler flowmetry and transcutaneous oximetry was used for discriminating between total blood flow and perfusion of the nutritive bed. Both methods reveal increasing skin microcirculation perfusion due to insulin infusion with this effect rising non-linearly with increasing insulinemia.
Publish Date	2013-12-20 16:49
Citation	Kr?ma M, ?echurová D, Bro?ová J, Jankovec Z, Lacigová S, ?ourek M, Ru?avy Z. Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers. World J Diabetes 2013; 4(6): 372-377 Available from: URL: http://www.wjgnet.com/1948-9358/full/v4/i6/372.htm DOI: http://dx.doi.org/10.4239/wjd.v4.i6.372
URL	http://www.wjgnet.com/1948-9358/full/v4/i6/372.htm
DOI	http://dx.doi.org/10.4239/wjd.v4.i6.372

Full Article (PDF)	WJD-4-372.pdf
Full Article (Word)	WJD-4-372.doc
Manuscript File	3933-Review.doc
Answering Reviewers	3933-Answering reviewers.pdf
Copyright License Agreement	3933-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3933-Language certificate.pdf
Peer-review Report	3933-Peer reviewer(s).pdf
Scientific Editor Work List	3933-Scientific editor work list.doc