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7/28/2020 2:46:56 PM | Browse: 395 | Download: 660
Publication Name World Journal of Gastroenterology
Manuscript ID 39332
Country/Territory United States
2020-03-30 17:14
Peer-Review Started
2020-03-30 17:17
To Make the First Decision
Return for Revision
2020-04-25 03:58
2020-06-08 02:49
Second Decision
2020-07-14 09:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-14 23:34
Articles in Press
2020-07-14 23:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-28 07:27
Publish the Manuscript Online
2020-07-28 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation
Manuscript Source Unsolicited Manuscript
All Author List John Aranake-Chrisinger, Themistocles Dassopoulos, Yan Yan and ILKe Nalbantoglu
Author(s) ORCID Number
John Aranake-Chrisinger http://orcid.org/0000-0002-7138-0923
Themistocles Dassopoulos http://orcid.org/0000-0003-2968-0321
Yan Yan http://orcid.org/0000-0002-5917-1475
ILKe Nalbantoglu http://orcid.org/0000-0002-9640-8822
Funding Agency and Grant Number
Corresponding Author ILKe Nalbantoglu, MD, Associate Professor, Department of Surgical Pathology, Yale University School of Medicine, 20 York Street, EP2-608B, New Haven, CT, 06510, United States. ilke.nalbantoglu@yale.edu
Key Words Primary sclerosing cholangitis; Inflammatory bowel disease; Liver transplantation; Inflammation; Pathologic features; Clinical associations
Core Tip This is a retrospective study evaluating biopsies and clinical features of primary sclerosing cholangitis (PSC) patients with and without inflammatory bowel disease (IBD) in comparison to subjects with ulcerative colitis (UC) or Crohn disease (CD). Patients with PSC-UC had a different disease distribution characterized by right sided colitis, a milder disease course with lower activity scores in biopsies, less need for colectomy, and steroids compared to UC. PSC-CD patients were rare but had more ileal inflammation compared to PSC-UC. PSC-No IBD patients showed similar characteristics to PSC patients in general and only one patient received orthotopic liver transplantation (OLT) in this group. Ten PSC-UC patients received OLT in contrast to no patients with PSC-CD. The need for OLT in PSC-IBD (PSC-UC and PSC-CD) correlated with rectal involvement and higher activity scores in the left colon biopsies in comparison to patients without OLT. This may require clinical attention since the both the intestinal and liver disease seem to be “severe” in this group further supporting the importance of gut-liver interaction in these patients.
Publish Date 2020-07-28 14:46
Citation Aranake-Chrisinger J, Dassopoulos T, Yan Y, Nalbantoglu I. Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation. World J Gastroenterol 2020; 26(28): 4126-4139
URL https://www.wjgnet.com/1007-9327/full/v26/i28/4126.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i28.4126
Full Article (PDF) WJG-26-4126.pdf
Full Article (Word) WJG-26-4126.docx
Manuscript File 39332-Review.docx
Answering Reviewers 39332-Answering reviewers.pdf
Audio Core Tip 39332-Audio core tip.wav
Biostatistics Review Certificate 39332-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39332-Conflict-of-interest statement.pdf
Copyright License Agreement 39332-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 39332-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 39332-Institutional review board statement.pdf
Peer-review Report 39332-Peer-review(s).pdf
Scientific Misconduct Check 39332-Bing-Fan FX-1.png
Scientific Misconduct Check 39332-Bing-Liu M-2.png
Scientific Misconduct Check 39332-Scientific misconduct check.pdf
Scientific Editor Work List 39332-Scientific editor work list.pdf