Publication Name	World Journal of Gastroenterology
Manuscript ID	39345
Country	China

Received	2018-04-13 01:00
Peer-Review Started	2018-04-13 06:29
To Make the First Decision	2018-05-09 04:13
Return for Revision	2018-05-16 09:39
Revised	2018-05-26 14:52
Second Decision	2018-06-27 09:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-06-27 17:29
Articles in Press	2018-06-27 17:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-02 21:39
Typeset the Manuscript	2018-07-18 02:47
Publish the Manuscript Online	2018-07-19 07:04

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”
Manuscript Source	Invited Manuscript
All Author List	Yan-Lan Fang, Hong Chen, Chun-Lin Wang and Li Liang
ORCID	Author(s) ORCID Number Yan-Lan Fang http://orcid.org/0000-0001-6579-417X Hong Chen http://orcid.org/0000-0002-8678-2722 Chun-Lin Wang http://orcid.org/0000-0002-8288-3075 Li Liang http://orcid.org/0000-0002-2074-7406
Funding Agency and Grant Number	Funding Agency Grant Number The National Key Research And Development Program of China 2016YFC1305301
Corresponding Author	Li Liang, MD, Chief Doctor, Professor, Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zdliangli@zju.edu.cn
Key Words	Non-alcoholic steatohepatitis; Children; Adolescents; Pathogenesis; Nonalcoholic fatty liver disease
Core Tip	Much work on nonalcoholic fatty liver disease (NAFLD) has been done, but an accurate understanding of its mechanism remains unclear. Our objective was to examine the current literature to better understand the pathogenesis of NAFLD, thus showing how it evolved from the “two-hit theory” to a “multiple hit model”.
Publish Date	2018-07-19 07:04
Citation	Fang YL, Chen H, Wang CL, Liang L. Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”. World J Gastroenterol 2018; 24(27): 2974-2983
URL	http://www.wjgnet.com/1007-9327/full/v24/i27/2974.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i27.2974

Full Article (PDF)	WJG-24-2974.pdf
Full Article (Word)	WJG-24-2974.doc
Manuscript File	39345-Review.doc
Answering Reviewers	39345-Answering reviewers.pdf
Audio Core Tip	39345-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	39345-Conflict-of-interest statement.pdf
Copyright License Agreement	39345-Copyright License Agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39345-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	39345-Language certificate.pdf
Peer-review Report	39345-Peer-review(s).pdf
Scientific Misconduct Check	39345-Scientific misconduct check.pdf
Scientific Editor Work List	39345-Scientific editor work list.pdf