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Articles Published Processes
8/3/2018 11:25:35 AM | Browse: 841 | Download: 1367
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Received |
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2018-04-23 01:25 |
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Peer-Review Started |
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2018-04-23 12:12 |
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To Make the First Decision |
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2018-05-09 04:35 |
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Return for Revision |
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2018-05-12 10:12 |
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Revised |
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2018-06-03 07:30 |
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Second Decision |
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2018-06-25 08:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-06-25 19:08 |
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Articles in Press |
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2018-06-25 19:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-07-02 20:45 |
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Typeset the Manuscript |
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2018-08-03 02:41 |
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Publish the Manuscript Online |
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2018-08-03 11:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui-Zhong Zhang, Xin-Hao Zeng, Ze-Feng Lin, Ming Fu, Yan-Lu Tong, Vincent CH Lui, Paul KH Tam, Jonathan R Lamb, Hui-Ming Xia and Yan Chen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project of Guangzhou |
201707010014 |
| National Natural Science Foundation of China |
81600399 |
| National Natural Science Foundation of China |
81671498 |
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| Corresponding Author |
Yan Chen, PhD, Honorary Research Fellow, Senior Scientist, Department of Surgery, the University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong , China. ychenc@hku.hk |
| Key Words |
Biliary atresia; Rhesus rotavirus; Hes1; EpCAM; Epithelial cells 3D culture |
| Core Tip |
Similar immature biliary epithelial cells and distorted bile ductules were observed in biliary atresia patients and a mouse biliary atresia model. Investigation of the Notch signaling pathway target gene Hes1 showed that mRNA and protein expression was reduced in mouse liver, which was partially due to reduced expression of transcriptional co-regulator RBP-Jκ. In biliary epithelial cells 3D gel culture system, the administration of Hes1 siRNA blocked the maturation and duct-like structure formation process, which resulted in the cells still being in an immature state and no duct-like structure was observed. |
| Publish Date |
2018-08-03 11:25 |
| Citation |
Zhang RZ, Zeng XH, Lin ZF, Fu M, Tong YL, Lui VC, Tam PK, Lamb JR, Xia HM, Chen Y. Downregulation of Hes1 expression in experimental biliary atresia and its effects on bile duct structure. World J Gastroenterol 2018; 24(29): 3260-3272 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i29/3260.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i29.3260 |
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