| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Minireviews |
| Article Title |
Gastrointestinal toxicity induced by microcystins
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Xia Wu, Hui Huang, Lei Yang, Xiao-Feng Zhang, Shen-Shen Zhang, Hao-Hao Liu, Yue-Qin Wang, Le Yuan, Xue-Min Cheng, Dong-Gang Zhuang and Hui-Zhen Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81773384 and 81472948 |
| Scientific and Technological Project of Henan Province |
142102310344 |
|
| Corresponding Author |
Hui-Zhen Zhang, PhD, Professor, Department of Environmental Hygiene, College of Public Health, Zhengzhou University, No. 100 Science Avenue, Zhengzhou 450001, Henan Province, China. huizhenzhang@zzu.edu.cn |
| Key Words |
Immunotoxicity; Gastrointestinal toxicity; Intestine; Depuration; Oxidative stress; Microcystins |
| Core Tip |
First, the gastrointestinal toxicity of microcystins (MCs) on a population was described. Second, the concentration or localization of MCs in the small intestine after exposure to various concentrations and different time points, as well as after the depuration of MCs in the intestine, was summarized. Third, the change in morphologic pathology and other effects such as oxidative stress, immunotoxicity, digestive enzymes, and gut microbiota in the intestine with exposure to MCs were discussed. Further challenges that need to be addressed were also summarized. |
| Publish Date |
2018-09-26 09:00 |
| Citation |
Wu JX, Huang H, Yang L, Zhang XF, Zhang SS, Liu HH, Wang YQ, Yuan L, Cheng XM, Zhuang DG, Zhang HZ. Gastrointestinal toxicity induced by microcystins. World J Clin Cases 2018; 6(10): 344-354 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i10/344.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i10.344 |
