Publication Name	World Journal of Gastroenterology
Manuscript ID	39426
Country	China

Received	2018-04-20 08:12
Peer-Review Started	2018-04-20 08:17
To Make the First Decision	2018-06-06 02:17
Return for Revision	2018-06-11 08:17
Revised	2018-06-16 07:04
Second Decision	2018-06-27 09:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-06-27 17:28
Articles in Press	2018-06-27 17:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-07-06 18:04
Typeset the Manuscript	2018-08-03 02:42
Publish the Manuscript Online	2018-08-03 11:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	his article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Wei-Yu Xu, Hao-Hai Zhang, Jian-Ping Xiong, Xiao-Bo Yang, Yi Bai, Jian-Zhen Lin, Jun-Yu Long, Yong-Chang Zheng, Hai-Tao Zhao and Xin-Ting Sang
ORCID	Author(s) ORCID Number Wei-Yu Xu http://orcid.org/0000-0002-2101-4829 Hao-Hai Zhang http://orcid.org/0000-0002-5292-6505 Jian-Ping Xiong http://orcid.org/0000-0002-6163-2621 Xiao-Bo Yang http://orcid.org/0000-0003-1929-8866 Yi Bai http://orcid.org/0000-0002-1179-3734 Jian-Zhen Lin http://orcid.org/0000-0002-4767-8834 Jun-Yu Long http://orcid.org/0000-0001-5745-7165 Yong-Chang Zheng http://orcid.org/0000-0002-6956-1186 Hai-Tao Zhao http://orcid.org/0000-0002-3444-8044 Xin-Ting Sang http://orcid.org/0000-0003-1952-0527
Funding Agency and Grant Number	Funding Agency Grant Number National key project research and development projects S2016G9012 International Science and Technology Cooperation Projects 2015DFA30650 The Capital Special Research Project for Clinical Application Z151100004015170
Corresponding Author	Xin-Ting Sang, MD, Professor, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 1Shuaifuyuan, Wangfujing, Beijing 100730, China. sangxt@pumch.cn
Key Words	Gallbladder cancer; Fibrinogen; Albumin; Fibrinogen-to-albumin ratio; Prognosis; Survival
Core Tip	The vital prognostic significance of fibrinogen and serum albumin has been confirmed in diverse ma­lignancies, presenting host hemostasis and nutrition, respectively. Moreover, elevated plasma fibrinogen and reduced serum albumin levels are significantly related to shortened survival of cancer patients. It is reported that fibrinogen-to-albumin ratio (FAR) is more potent in predicting cancer patient prognosis than elevated fibrinogen or reduced serum albumin level alone. Nevertheless, there has been no study on the prognostic role of FAR in gallbladder cancer (GBC). Herein, we defined an elevated preoperative FAR, featured by noninvasiveness, cost-effectiveness and easily-accessible, which was a potential prognostic indicator for GBC.
Publish Date	2018-08-03 11:25
Citation	Xu WY, Zhang HH, Xiong JP, Yang XB, Bai Y, Lin JZ, Long JY, Zheng YC, Zhao HT, Sang XT. Prognostic significance of the fibrinogen-to-albumin ratio in gallbladder cancer patients. World J Gastroenterol 2018; 24(29): 3281-3292
URL	http://www.wjgnet.com/1007-9327/full/v24/i29/3281.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i29.3281

Full Article (PDF)	WJG-24-3281.pdf
Full Article (Word)	WJG-24-3281.doc
Manuscript File	39426-Review.docx
Answering Reviewers	39426-Answering reviewers.pdf
Audio Core Tip	39426-Audio core tip.mp3
Biostatistics Review Certificate	39426-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39426-Conflict-of-interest statement.pdf
Copyright License Agreement	39426-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39426-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	39426-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	39426-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	39426-Language certificate.pdf
Peer-review Report	39426-Peer-review(s).pdf
Scientific Misconduct Check	39426-Scientific misconduct check.pdf
Scientific Editor Work List	39426-Scientific editor work list.pdf