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9/7/2018 1:56:18 AM | Browse: 815 | Download: 1071
Publication Name World Journal of Clinical Cases
Manuscript ID 39455
Country/Territory Türkiye
Received
2018-04-27 08:35
Peer-Review Started
2018-04-27 09:26
To Make the First Decision
2018-06-15 02:44
Return for Revision
2018-06-15 03:27
Revised
2018-06-23 16:12
Second Decision
2018-07-26 14:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-08-01 13:54
Articles in Press
2018-08-01 13:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-08-07 18:15
Typeset the Manuscript
2018-09-02 09:01
Publish the Manuscript Online
2018-09-07 01:56
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Impact of sorafenib on epidural fibrosis: An immunohistochemical study
Manuscript Source Unsolicited Manuscript
All Author List Osman Tanriverdi, Uzay Erdogan, Canan Tanik, Ilhan Yilmaz, Omur Gunaldi, Huseyin Utku Adilay, Ayca Arslanhan and Metehan Eseoglu
ORCID
Author(s) ORCID Number
Osman Tanriverdi http://orcid.org/0000-0002-4846-4213
Uzay Erdogan http://orcid.org/0000-0001-8268-6306
Canan Tanik http://orcid.org/0000-0003-2435-7533
Ilhan Yilmaz http://orcid.org/0000-0001-5548-2228
Omur Gunaldi http://orcid.org/0000-0001-5071-1319
Huseyin Utku Adilay http://orcid.org/0000-0003-4867-244X
Ayca Arslanhan http://orcid.org/0000-0002-3980-0609
Metehan Eseoglu http://orcid.org/0000-0003-0260-1988
Funding Agency and Grant Number
Corresponding Author Osman Tanriverdi, MD, Doctor, Department of Neurosurgery and Psychiatry, University of Health Sciences, Bakırköy Prof. Dr. Mazhar Osman Training and Research Hospital for Neurology, Tevfik sağlam cad. No. 1, İstanbul 34303, Türkiye. osmantanriverdi74@gmail.com
Key Words Vascular endothelial growth factor; CD105; Osteopontin; Sorafenib; Spinal epidural fibrosis
Core Tip This study addressed the prevention of spinal epidural fibrosis (EF) by sorafenib, an antineoplastic agent, though immunohistochemical analyses of EF as a consequence of laminectomy in rats. The study demonstrated for the first time that the fibrosis thickness, inflammatory cell density, arachnoid adherences, fibrosis scores, and vessel count were significantly lower in the treatment group. These findings indicate that locally administered sorafenib may help reduce spinal EF after laminectomy without any significant complications or side effects.
Publish Date 2018-09-07 01:56
Citation Tanriverdi O, Erdogan U, Tanik C, Yilmaz I, Gunaldi O, Adilay HU, Arslanhan A, Eseoglu M. Impact of sorafenib on epidural fibrosis: An immunohistochemical study. World J Clin Cases 2018; 6(9): 249-258
URL http://www.wjgnet.com/2307-8960/full/v6/i9/249.htm
DOI http://dx.doi.org/10.12998/wjcc.v6.i9.249
Full Article (PDF) WJCC-6-249.pdf
Full Article (Word) WJCC-6-249.doc
Manuscript File 39455-Review.docx
Answering Reviewers 39455-Answering reviewers.pdf
Audio Core Tip 39455-Audio core tip.mp3
Biostatistics Review Certificate 39455-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39455-Conflict-of-interest statement.pdf
Copyright License Agreement 39455-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 39455-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 39455-Institutional Review Board Approval Form or Document.pdf
Non-Native Speakers of English Editing Certificate 39455-Language certificate.pdf
Peer-review Report 39455-Peer-review(s).pdf
Scientific Misconduct Check 39455-Scientific misconduct check.pdf
Scientific Editor Work List 39455-Scientific editor work list.pdf