Publication Name	World Journal of Surgical Procedures
Manuscript ID	3946
Country	Japan

Received	2013-06-04 08:30
Peer-Review Started	2013-06-04 16:09
To Make the First Decision	2013-06-24 10:32
Return for Revision	2013-07-17 15:24
Revised	2013-07-31 19:19
Second Decision	2013-09-16 14:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 05:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-10 15:43
Publish the Manuscript Online	2013-12-11 16:18

ISSN	2219-2832 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Platelet therapy: A novel strategy for liver regeneration, anti-fibrosis, and anti-apoptosis
Manuscript Source	Invited Manuscript
All Author List	Kazuhiro Takahashi, Soichiro Murata and Nobuhiro Ohkohchi
Funding Agency and Grant Number
Corresponding Author	Nobuhiro Ohkohchi, MD, PhD, Professor, Department of Surgery, Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan. nokochi3@md.tsukuba.ac.jp
Key Words	Platelet therapy; Liver regeneration; Liver fibrosis; Hepatocyte apoptosis; Growth factor
Core Tip	Platelets have conventionally been considered to exacerbate the inflammatory response and liver injury. Recently, some studies have demonstrated a role for platelets in promoting liver regeneration, improving liver fibrosis, and attenuating hepatitis. In this review, the experimental and clinical evidence that platelets accelerate liver regeneration and attenuate fibrosis and apoptosis are described, as are the mechanisms of action. Platelet therapies, such as thrombopoietin, thrombopoietin receptor agonists, and platelet transfusion, will play a promising role in the treatment of the various liver disorders that currently challenge the surgical field.
Publish Date	2013-12-11 16:18
Citation	Takahashi K, Murata S, Ohkohchi N. Platelet therapy: A novel strategy for liver regeneration, anti-fibrosis, and anti-apoptosis. World J Surg Proced 2013; 3(3): 29-36
URL	http://www.wjgnet.com/2219-2832/full/v3/i3/29.htm
DOI	http://dx.doi.org/10.5412/wjsp.v3.i3.29

Full Article (PDF)	WJSP-3-29.pdf
Manuscript File	3946-Review.docx
Answering Reviewers	3946-Answering reviewers.pdf
Copyright License Agreement	3946-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	3946-Language certificate.pdf
Peer-review Report	3946-Peer reviewer(s).pdf
Scientific Editor Work List	3946-Scientific editor work list.doc