ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
High expression of type I inositol 1,4,5-trisphosphate receptor in the kidney of rats with hepatorenal syndrome
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Jing-Bo Wang, Ye Gu, Ming-Xiang Zhang, Shun Yang, Yan Wang, Wei Wang, Xi-Ran Li, Yi-Tong Zhao and Hai-Tao Wang |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Natural Science Foundation of Liaoning Province |
20170540826 |
Science and Technology Program of Shenyang City |
18-014-4-49 |
Innovation Support Program of Shenyang City for Young and Middle-aged Researchers |
RC170051 |
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Corresponding Author |
Hai-Tao Wang, MSc, Surgeon, Department of General Surgery, the Second Affiliated Hospital of Shenyang Medical College, Beijiuma Road, Heping District, Shenyang 110002, Liaoning Province, China. whtszyypwk@163.com |
Key Words |
Hepatorenal syndrome; Type I inositol 1,4,5-trisphosphate receptor; Glomerular mesangial cells; Vascular smooth muscle cells |
Core Tip |
Type I inositol 1,4,5-trisphosphate receptor (IP3RI) protein expression is increased in the kidney of hepatorenal syndrome (HRS) rats, and IP3RI protein expression may be regulated at the transcriptional level. Increased expression of IP3RI may be closely associated with HRS development and progression through excessive renal vascular contraction resulting in insufficient renal blood perfusion. |
Publish Date |
2018-08-03 11:25 |
Citation |
Wang JB, Gu Y, Zhang MX, Yang S, Wang Y, Wang W, Li XR, Zhao YT, Wang HT. High expression of type I inositol 1,4,5-trisphosphate receptor in the kidney of rats with hepatorenal syndrome. World J Gastroenterol 2018; 24(29): 3273-3280 |
URL |
http://www.wjgnet.com/1007-9327/full/v24/i29/3273.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v24.i29.3273 |