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8/13/2018 7:45:11 AM | Browse: 226 | Download: 261
Publication Name World Journal of Gastroenterology
Manuscript ID 39466
Country/Territory China
Received
2018-05-04 02:30
Peer-Review Started
2018-05-04 07:54
To Make the First Decision
2018-05-23 06:13
Return for Revision
2018-05-25 10:59
Revised
2018-06-08 01:01
Second Decision
2018-06-25 11:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-25 18:48
Articles in Press
2018-06-25 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-05 18:32
Typeset the Manuscript
2018-08-08 03:12
Publish the Manuscript Online
2018-08-13 07:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Observational Study
Article Title Altered oral microbiota in chronic hepatitis B patients with different tongue coatings
Manuscript Source Unsolicited Manuscript
All Author List Yu Zhao, Yu-Feng Mao, Yi-Shuang Tang, Ming-Zhu Ni, Qiao-Hong Liu, Yan Wang, Qin Feng, Jing-Hua Peng and Yi-Yang Hu
ORCID
Author(s) ORCID Number
Yu Zhao http://orcid.org/0000-0002-2208-2882
Yu-Feng Mao http://orcid.org/0000-0002-8604-9096
Yi-Shuang Tang http://orcid.org/0000-0001-5125-8376
Ming-Zhu Ni http://orcid.org/0000-0002-5675-953X
Qiao-Hong Liu http://orcid.org/0000-0001-9887-8126
Yan Wang http://orcid.org/0000-0002-6710-8695
Qin Feng http://orcid.org/0000-0002-4641-1636
Jing-Hua Peng http://orcid.org/0000-0002-0665-7666
Yi-Yang Hu http://orcid.org/0000-0001-9127-7002
Funding Agency and Grant Number
Funding Agency Grant Number
Shanghai Educational Development Foundation 14CG41
National Natural Science Foundation of China 81403298, 81373857
National Science and Technology Major Project 2017ZX09304002
Corresponding author Yi-Yang Hu, MD, PhD, Doctor, Senior Researcher, Institute of Liver Diseases,Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No.528 Zhangheng Road, Pudong New Area, Shanghai 201203, China. yyhuliver@163.com
Keywords 16S rRNA gene sequencing; Metabolomics; Chronic hepatitis B; Tongue diagnosis; Microbiota
Core Tip Tongue diagnosis has important guiding signif­icance for clinical syndrome differentiation and drug use in traditional Chinese medicine (TCM), but lacks scientific explanations. This study illustrates the existence of spe­cific clinical features and bacterial structure in chronic hepatitis B (CHB) patients with different tongue coatings. Compared with the CHB white tongue coating patients, the yellow tongue coating patients had higher viral titers and a significantly lower level of Bacteroidetes and higher level of Proteobacteria in their microbial compositions at the phylum level. This study explores the micro-features between different tongue coatings, which will promote our understanding of the TCM tongue diagnosis and facilitate therapeutic strategies for individualized treatment.
Publish Date 2018-08-13 07:45
Citation Zhao Y, Mao YF, Tang YS, Ni MZ, Liu QH, Wang Y, Feng Q, Peng JH, Hu YY. Altered oral microbiota in chronic hepatitis B patients with different tongue coatings. World J Gastroenterol 2018; 24(30): 3448-3461
Url http://www.wjgnet.com/1007-9327/full/v24/i30/3448.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i30.3448
Full Article (PDF) WJG-24-3448.pdf
Manuscript File 39466-Review.docx
Answering Reviewers 39466-Answering reviewers.pdf
Audio Core Tip 39466-Audio core tip.mp3
Biostatistics Review Certificate 39466-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39466-Conflict-of-interest statement.pdf
Copyright License Agreement 39466-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 39466-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 39466-Signed-Informed-Consent-Form(s)-or-Document(s)-revision.pdf
Institutional Review Board Approval Form or Document 39466-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 39466-Language certificate.pdf
Supplementary Material 39466-Supplementary material.pdf
Peer-review Report 39466-Peer-review(s).pdf
Scientific Misconduct Check 39466-Scientific misconduct check.pdf
Scientific Editor Work List 39466-Scientific editor work list.pdf