| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Altered oral microbiota in chronic hepatitis B patients with different tongue coatings
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Zhao, Yu-Feng Mao, Yi-Shuang Tang, Ming-Zhu Ni, Qiao-Hong Liu, Yan Wang, Qin Feng, Jing-Hua Peng and Yi-Yang Hu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Educational Development Foundation |
14CG41 |
| National Natural Science Foundation of China |
81403298, 81373857 |
| National Science and Technology Major Project |
2017ZX09304002 |
|
| Corresponding Author |
Yi-Yang Hu, MD, PhD, Doctor, Doctor, Senior Researcher, Institute of Liver Diseases,Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No.528 Zhangheng Road, Pudong New Area, Shanghai 201203, China. yyhuliver@163.com |
| Key Words |
16S rRNA gene sequencing; Metabolomics; Chronic hepatitis B; Tongue diagnosis; Microbiota |
| Core Tip |
Tongue diagnosis has important guiding significance for clinical syndrome differentiation and drug use in traditional Chinese medicine (TCM), but lacks scientific explanations. This study illustrates the existence of specific clinical features and bacterial structure in chronic hepatitis B (CHB) patients with different tongue coatings. Compared with the CHB white tongue coating patients, the yellow tongue coating patients had higher viral titers and a significantly lower level of Bacteroidetes and higher level of Proteobacteria in their microbial compositions at the phylum level. This study explores the micro-features between different tongue coatings, which will promote our understanding of the TCM tongue diagnosis and facilitate therapeutic strategies for individualized treatment. |
| Publish Date |
2018-08-13 07:45 |
| Citation |
Zhao Y, Mao YF, Tang YS, Ni MZ, Liu QH, Wang Y, Feng Q, Peng JH, Hu YY. Altered oral microbiota in chronic hepatitis B patients with different tongue coatings. World J Gastroenterol 2018; 24(30): 3448-3461 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i30/3448.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i30.3448 |
