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Articles Published Processes
9/7/2018 9:21:44 AM | Browse: 1001 | Download: 1450
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Received |
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2018-04-21 04:54 |
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Peer-Review Started |
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2018-04-21 12:28 |
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To Make the First Decision |
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2018-05-18 01:11 |
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Return for Revision |
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2018-05-22 00:30 |
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Revised |
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2018-07-06 17:39 |
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Second Decision |
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2018-07-26 09:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-08-01 05:10 |
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Articles in Press |
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2018-08-01 05:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-08-13 22:58 |
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Typeset the Manuscript |
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2018-09-04 11:20 |
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Publish the Manuscript Online |
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2018-09-07 09:21 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Basic Study |
| Article Title |
Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ameya P Patil, William E Sweeney Jr, Cynthia G Pan and Ellis D Avner |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Children’s Research Institute, the Lillian Goldman Charitable Trust |
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| Amy P Goldman Foundation |
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| Ellsworth Family and Children’s Foundation of Children’s Hospital and Health System of Wisconsin |
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| Corresponding Author |
Ameya P Patil, MD, Assistant Professor, Department of Pediatrics, Medical College of Wisconsin, Children’s Research Institute, Children’s’ Hospital Health System of Wisconsin, Children’s Corporate Center, Suite 510, Mailstop CCC C510, 999 North 92nd Street, Milwaukee, WI 53226, United States. appatil@mcw.edu |
| Key Words |
Inflammation; End-stage renal disease; Cysts; Autosomal dominant polycystic kidney disease; miRNA; Renal interstitial fibrosis |
| Core Tip |
An essential and consistent histologic feature of progressive autosomal dominant polycystic kidney disease (ADPKD) is interstitial inflammation and fibrosis. This study investigated miRNA expression in local peri-cystic areas between cysts that become fibrotic as the disease progresses. This study identifies a critical limitation to whole organ transcriptomic approaches and demonstrates that laser capture microdissection (LCM) provides a means to overcome the dilutional factor of whole organ miRNA analysis. The precision of LCM provides a unique miRNA signature, which identifies novel molecular and therapeutic targets that initiate and drive interstitial fibrosis in ADPKD. |
| Publish Date |
2018-09-07 09:21 |
| Citation |
Patil A, Sweeney Jr WE, Pan CG, Avner ED. Unique interstitial miRNA signature drives fibrosis in a murine model of autosomal dominant polycystic kidney disease. World J Nephrol 2018; 7(5): 108-116 |
| URL |
http://www.wjgnet.com/2220-6124/full/v7/i5/108.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v7.i5.108 |
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