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9/14/2018 5:53:04 AM | Browse: 872 | Download: 1668
Publication Name World Journal of Gastroenterology
Manuscript ID 39491
Country China
Received
2018-05-07 01:01
Peer-Review Started
2018-05-07 03:20
To Make the First Decision
2018-05-23 06:14
Return for Revision
2018-05-25 11:10
Revised
2018-06-16 06:51
Second Decision
2018-06-26 11:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2018-06-27 04:10
Articles in Press
2018-06-27 04:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-19 18:30
Typeset the Manuscript
2018-09-03 08:11
Publish the Manuscript Online
2018-09-14 05:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Yuan-Feng Zeng, Yi-Sheng Xiao, Yong Liu, Xiao-Jiang Luo, Li-Dan Wen, Qian Liu and Ming Chen
ORCID
Author(s) ORCID Number
Yuan-Feng Zeng http://orcid.org/0000-0003-4174-3575
Yi-Sheng Xiao http://orcid.org/0000-0002-9487-0175
Yong Liu http://orcid.org/0000-0002-6162-6168
Xiao-Jiang Luo http://orcid.org/0000-0002-4894-4575
Li-Dan Wen http://orcid.org/0000-0003-1531-1904
Qian Liu http://orcid.org/0000-0003-1149-0650
Ming Chen http://orcid.org/0000-0002-5345-0991
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81201972
Postdoctoral Science Foundation of China 2013M531555
Postdoctoral Science Foundation of Jiangxi Province 2013KY44
Corresponding Author Yuan-Feng Zeng, PhD, Chief Doctor, Department of Pathology, Jiangxi Provincial People's Hospital, 152 Patriotic Road, Donghu District, Nanchang 330006, Jiangxi Province, China. zyf760928@163.com
Key Words Formin-like 3; Colorectal carcinoma; Invasion; RhoC/FAK pathway; Actin assembly
Core Tip Formin-like 3 (FMNL3) belongs to the subfamily of diaphanous-related formins, which govern the actin-dependent processes, including cell motility and invasion. The increased expression of FMNL3 in colorectal car¬cinoma (CRC) was shown to contribute to metastasis and poor prognosis of patients in previous studies, however its regulatory mechanism remains unclear. This work reveals that FMNL3 plays a positive role in CRC cell proliferation, invasion and migration. Moreover, FMNL3 activates the RhoC/FAK signaling pathway, and also regulates RhoC-dependent remodeling of actin-based protrusion, such as filopodia and lamellipodia, to promote CRC cell invasion. FMNL3 can be applied as a promising specific biomarker for CRC progression and metastasis.
Publish Date 2018-09-14 05:53
Citation Zeng YF, Xiao YS, Liu Y, Luo XJ, Wen LD, Liu Q, Chen M. Formin-like 3 regulates RhoC/FAK pathway and actin assembly to promote cell invasion in colorectal carcinoma. World J Gastroenterol 2018; 24(34): 3884-3897
URL http://www.wjgnet.com/1007-9327/full/v24/i34/3884.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i34.3884
Full Article (PDF) WJG-24-3884.pdf
Full Article (Word) WJG-24-3884.doc
The ARRIVE Guidelines 39491-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 39491-Review.doc
Answering Reviewers 39491-Answering reviewers.pdf
Audio Core Tip 39491-Audio core tip.m4a
Biostatistics Review Certificate 39491-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39491-Conflict-of-interest statement.pdf
Copyright License Agreement 39491-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 39491-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 39491-Institutional-Animal-Care-and-Use-Committee-Approval-Form-or-Document-revision.pdf
Institutional Review Board Approval Form or Document 39491-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 39491-Language certificate.pdf
Supplementary Material 39491-Supplementary material.pdf
Peer-review Report 39491-Peer-review(s).pdf
Scientific Misconduct Check 39491-Scientific misconduct check.pdf
Scientific Editor Work List 39491-Scientific editor work list.pdf