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8/16/2018 11:54:24 AM | Browse: 243 | Download: 294
Publication Name World Journal of Clinical Cases
Manuscript ID 39503
Country/Territory China
Received
2018-04-24 02:32
Peer-Review Started
2018-04-24 05:42
To Make the First Decision
2018-05-11 01:10
Return for Revision
2018-05-14 01:35
Revised
2018-05-16 15:51
Second Decision
2018-06-07 12:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-08 04:31
Articles in Press
2018-06-08 04:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-08-13 07:21
Publish the Manuscript Online
2018-08-16 11:54
ISSN 2307-8960 (online)
Open Access
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease
Manuscript Source Unsolicited Manuscript
All Author List Jin-Zhi Wang, Hai-Xia Cao, Jian-Neng Chen and Qin Pan
ORCID
Author(s) ORCID Number
Jin-Zhi Wang http://orcid.org/0000-0002-5035-5956
Hai-Xia Cao http://orcid.org/0000-0002-8265-9460
Jian-Neng Chen http://orcid.org/0000-0002-0728-0813
Qin Pan http://orcid.org/0000-0001-5855-4952
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Research and Development Plan ‘Precision Medicine Research’ No. 2017YFC0908903
National Natural Science Foundation of China 81070346
National Natural Science Foundation of China 81270492
National Natural Science Foundation of China 81470859
National Natural Science Foundation of China 81270491
National Natural Science Foundation of China 81470840
State Key Development Program for Basic Research of China No. 2012CB517501
100 Talents Program No. XBR2011007h
Program of the Committee of Science and Technology No. 09140903500
Corresponding author Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn
Keywords Non-alcoholic fatty liver disease; Patatin-like phospholipase domain-containing protein 3; Treatment; Lifestyle; Pharmacotherapy; Surgery; Polymorphism
Core Tip Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 imposes universal, yet distinctly different, impact on various therapies in nonalcoholic fatty liver disease (NAFLD) patients. As compared to those with C-allele, patients with PNPLA3 rs738409 G-allele (PNPLA3 148M variant) show grater improvement in response to lifestyle modification, dipeptidyl peptidase-4 inhibitor ingestion, and bariatric surgery. In contrast, NAFLD patients carrying PNPLA3 rs738409 C-allele (PNPLA3 148I variant) are much sensitive to both omega-3 poly-unsaturated fatty acids and statin intervention. These diversities in treatment response warrant a personalized, precise medicine in NAFLD by stratification of PNPLA3 rs738409 genotype.
Publish Date 2018-08-16 11:54
Citation Wang JZ, Cao HX, Chen JN, Pan Q. PNPLA3 rs738409 under­lies treatment response in nonalcoholic fatty liver disease. World J Clin Cases 2018; 6(8): 167-175
Url http://www.wjgnet.com/2307-8960/full/v6/i8/167.htm
DOI http://dx.doi.org/10.12998/wjcc.v6.i8.167
Full Article (PDF) WJCC-6-167.pdf
Full Article (Word) WJCC-6-167.doc
Manuscript File 39503-Review.doc
Answering Reviewers 39503-Answering reviewers.pdf
Audio Core Tip 39503-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39503-Conflict-of-interest statement.pdf
Copyright License Agreement 39503-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 39503-Language certificate.pdf
Peer-review Report 39503-Peer-review(s).pdf
Scientific Misconduct Check 39503-Scientific misconduct check.pdf
Scientific Editor Work List 39503-Scientific editor work list.pdf