BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/16/2018 11:54:24 AM | Browse: 1146 | Download: 1551
 |
Received |
|
2018-04-24 02:32 |
|
Peer-Review Started |
|
2018-04-24 05:42 |
|
To Make the First Decision |
|
2018-05-11 01:10 |
|
Return for Revision |
|
2018-05-14 01:35 |
|
Revised |
|
2018-05-16 15:51 |
|
Second Decision |
|
2018-06-07 12:09 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2018-06-08 04:31 |
|
Articles in Press |
|
2018-06-08 04:31 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2018-08-13 07:21 |
|
Publish the Manuscript Online |
|
2018-08-16 11:54 |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Zhi Wang, Hai-Xia Cao, Jian-Neng Chen and Qin Pan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Plan ‘Precision Medicine Research’ |
No. 2017YFC0908903 |
| National Natural Science Foundation of China |
81070346 |
| National Natural Science Foundation of China |
81270492 |
| National Natural Science Foundation of China |
81470859 |
| National Natural Science Foundation of China |
81270491 |
| National Natural Science Foundation of China |
81470840 |
| State Key Development Program for Basic Research of China |
No. 2012CB517501 |
| 100 Talents Program |
No. XBR2011007h |
| Program of the Committee of Science and Technology |
No. 09140903500 |
|
| Corresponding Author |
Qin Pan, MD, PhD, Professor, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Kongjiang Road NO 1665, Yangpu District, Shanghai 200092, China. panqin@xinhuamed.com.cn |
| Key Words |
Non-alcoholic fatty liver disease; Patatin-like phospholipase domain-containing protein 3; Treatment; Lifestyle; Pharmacotherapy; Surgery; Polymorphism |
| Core Tip |
Patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 imposes universal, yet distinctly different, impact on various therapies in nonalcoholic fatty liver disease (NAFLD) patients. As compared to those with C-allele, patients with PNPLA3 rs738409 G-allele (PNPLA3 148M variant) show grater improvement in response to lifestyle modification, dipeptidyl peptidase-4 inhibitor ingestion, and bariatric surgery. In contrast, NAFLD patients carrying PNPLA3 rs738409 C-allele (PNPLA3 148I variant) are much sensitive to both omega-3 poly-unsaturated fatty acids and statin intervention. These diversities in treatment response warrant a personalized, precise medicine in NAFLD by stratification of PNPLA3 rs738409 genotype. |
| Publish Date |
2018-08-16 11:54 |
| Citation |
Wang JZ, Cao HX, Chen JN, Pan Q. PNPLA3 rs738409 underlies treatment response in nonalcoholic fatty liver disease. World J Clin Cases 2018; 6(8): 167-175 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i8/167.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i8.167 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
