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Articles Published Processes
8/17/2018 10:48:34 AM | Browse: 1186 | Download: 1589
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Received |
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2018-05-03 10:30 |
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Peer-Review Started |
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2018-05-04 03:44 |
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To Make the First Decision |
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2018-05-23 06:15 |
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Return for Revision |
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2018-05-25 11:17 |
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Revised |
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2018-06-01 07:48 |
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Second Decision |
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2018-06-25 11:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-06-25 18:46 |
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Articles in Press |
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2018-06-25 18:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2018-07-02 20:40 |
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Typeset the Manuscript |
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2018-08-16 06:54 |
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Publish the Manuscript Online |
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2018-08-17 10:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Review |
| Article Title |
Hepatitis B virus infection: defective surface antigen expression and pathogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Chen Wu, Ying-Shan Chen, Liang Cao, Xin-Wen Chen and Meng-Ji Lu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
31770180 |
| the Youth Innovation Promotion Association CAS |
201603 |
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| Corresponding Author |
Meng-Ji Lu, PhD, Professor, Institute of Virology, University Hospital of Essen, Hufelandstrasse 55, Essen 45122, Germany. mengji.lu@uni-due.de |
| Key Words |
Hepatitis B surface protein; Defective surface antigen mutants; Endoplasmic reticulum stress; Fulminant hepatitis B; Occult hepatitis B virus infection; Pathogenesis |
| Core Tip |
Defective surface antigen mutation is a type of mutation with great clinical relevance. Many previous publications have explored the association of defective surface antigen mutation with the development of hepatitis B virus (HBV)-associated hepatocellular carcinoma. However, there are no reviews available that elaborate on the relationship between defective surface antigen mutation and HBV-associated fulminant hepatitis (FH), as well as occult hepatitis B virus infection (OBI). This review will focus on these two aspects to discuss the nature of defective HBV surface antigen mutations and their contribution to the pathogenesis of FH. The relationship between defective surface antigens and OBI are also discussed. |
| Publish Date |
2018-08-17 10:48 |
| Citation |
Wu CC, Chen YS, Cao L, Chen XW, Lu MJ. Hepatitis B virus infection: defective surface antigen expression and pathogenesis. World J Gastroenterol 2018; 24(31): 3488-3499 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i31/3488.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i31.3488 |
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