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Articles Published Processes
8/3/2018 11:25:35 AM | Browse: 905 | Download: 1263
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Received |
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2018-05-02 10:07 |
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Peer-Review Started |
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2018-05-04 02:34 |
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To Make the First Decision |
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2018-05-17 02:58 |
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Return for Revision |
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2018-05-21 08:01 |
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Revised |
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2018-05-31 04:07 |
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Second Decision |
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2018-06-27 09:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-06-27 17:24 |
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Articles in Press |
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2018-06-27 17:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-08-03 02:41 |
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Publish the Manuscript Online |
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2018-08-03 11:25 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aleksandra Adamska and Marco Falasca |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Avner Pancreatic Cancer Foundation |
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| Corresponding Author |
Marco Falasca, PhD, Professor, Metabolic Signalling Group, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, GPO Box U1987, Perth 6102, WA, Australia. marco.falasca@curtin.edu.au |
| Key Words |
Pancreatic ductal adenocarcinoma; Multi-drug resistance; ATP-binding cassette transporters; Targeted therapies; Pancreatic ductal adenocarcinoma prognosis; Predictive markers |
| Core Tip |
Pancreatic cancer is one of the deadliest cancers due to its highly aggressive biology and resistance to broad range of therapeutics. Expression of ATP-binding cassette (ABC) transporters by cancer cells is one of the main mechanisms responsible for the lowered drug accumulation. However, the attempts made in multidrug resistance reversal by the inhibition of their activity have not provided satisfactory results in clinical trials. Nevertheless, current knowledge on the role played by ABC transporters in carcinogenesis beyond chemoresistance, could create the opportunity for the development of novel, direct targeted therapeutic strategies. Additionally, the association between ABC transporters expression and pancreatic ductal adenocarcinoma patients’ prognosis and response to applied therapies confirms their pharmacological potential. |
| Publish Date |
2018-08-03 11:25 |
| Citation |
Adamska A, Falasca M. ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer: What is the way forward? World J Gastroenterol 2018; 24(29): 3222-3238 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i29/3222.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i29.3222 |
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