| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Keizo Hiraishi, Lin Hai Kurahara, Miho Sumiyoshi, Yao-Peng Hu, Kaori Koga, Miki Onitsuka, Daibo Kojima, Li-Xia Yue, Hidetoshi Takedatsu, Yu-Wen Jian and Ryuji Inoue |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| MEXT KAKENHI |
15K08978 |
| MEXT KAKENHI |
22790677 |
| MEXT KAKENHI |
25860571 |
| MEXT-Supported Program supporting research activities of female researchers |
|
| Clinical Research Foundation |
|
| Central Research Institute of Fukuoka University |
151045 |
| Central Research Institute of Fukuoka University |
147104 |
|
| Corresponding Author |
Lin Hai Kurahara, PhD, Lecturer, Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, 7-45-1, Nanakuma, Johnan-ku, Fukuoka 814-0180, Fukuoka, Japan. hailin@fukuoka-u.ac.jp |
| Key Words |
Intestinal fibrosis; Myofibroblast; Transient receptor potential ankyrin 1; Crohn’s disease; Collagen; α-smooth muscle actin |
| Core Tip |
Active ingredients of the famous Chinese medicine Da-Jian-Zhong-Tang (Daikenchuto; DKT), i.e., hydroxy α-sanshool and 6-shogaol, induced Ca2+ influxes in intestinal myofibroblast (InMyoFib), which were antagonized by co-treatment with a selective transient receptor potential ankyrin 1 (TRPA1) channel blocker HC-030031. DKT counteracted the transforming growth factor (TGF)-β1-induced expression of Type Ⅰ collagen, α-smooth muscle actin (α-SMA), and this was accompanied by a reduction in fibrosis signaling downstream of the TGF-β1 receptor. Importantly, a 24-h incubation with another DKT active ingredient of Japanese Pepper increased mRNA and protein expression in TRPA1, which in turn negatively regulated collagen synthesis in InMyoFibs. In stenotic regions of the intestines of patients with Crohn’s disease, TRPA1 expression was significantly increased. |
| Publish Date |
2018-09-20 02:33 |
| Citation |
Hiraishi K, Kurahara LH, Sumiyoshi M, Hu YP, Koga K, Onitsuka M, Kojima D, Yue L, Takedatsu H, Jian YW, Inoue R. Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel. World J Gastroenterol 2018; 24(35): 4036-4053 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i35/4036.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i35.4036 |
