Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	39764
Country	United States

Received	2018-05-11 05:58
Peer-Review Started	2018-05-11 10:29
To Make the First Decision	2018-07-09 07:51
Return for Revision	2018-07-10 07:59
Revised	2018-08-08 17:18
Second Decision	2018-08-22 08:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-08-26 17:46
Articles in Press	2018-08-26 17:46
Publication Fee Transferred
Edit the Manuscript by Language Editor	2018-09-04 18:55
Typeset the Manuscript	2018-09-27 02:37
Publish the Manuscript Online	2018-09-28 00:52

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans
Manuscript Source	Unsolicited Manuscript
All Author List	Lulu Farhana, Fadi Antaki, Farhan Murshed, Hamidah Mahmud, Stephanie L Judd, Pratima Nangia-Makker, Edi Levi, Yingjie Yu and Adhip PN Majumdar
ORCID	Author(s) ORCID Number Lulu Farhana http://orcid.org/0000-0003-1057-8845 Fadi Antaki http://orcid.org/0000-0002-2273-9346 Farhan Murshed http://orcid.org/0000-0003-0334-7846 Hamidah Mahmud http://orcid.org/0000-0002-7834-8213 Stephanie L Judd http://orcid.org/0000-0001-7296-5694 Pratima Nangia-Makker http://orcid.org/0000-0002-1917-169X Edi Levi http://orcid.org/0000-0003-1809-2866 Yingjie Yu http://orcid.org/0000-0001-7497-7832 Adhip PN Majumdar http://orcid.org/0000-0002-6413-5102
Funding Agency and Grant Number	Funding Agency Grant Number NIH 1R21CA175916 Department of Veteran Affairs I101BX001927 Metropolitan Detroit Research and Education Fund MDREF
Corresponding Author	Adhip PN Majumdar, DSc, PhD, Professor, Department of Internal Medicine, John D Dingell Veterans Affairs Medical Center, 4646 John R, Detroit, MI 48201, United States. a.majumdar@wayne.edu
Key Words	Human gut; Microbiome; Colorectal cancer; Fusobacterium nucleatum; African Americans; 16S RNA profiling; Metagenomics
Core Tip	Several studies have demonstrated that the incidence of colorectal cancer (CRC) is higher in African Americans than Caucasian Americans. Reasons for this racial disparity are unknown. The current study, for the first time, demonstrated that dysbiosis in the gut microbiome plays a determinant role in the racial disparity of CRC. Determining the influence of the microbiota on the risk of developing CRC will have a major impact on health, since early-stage CRC hinges on the ability to detect early pathological changes. Subsequent translational studies could also be developed to alter microbiota with medications or diet, thus reducing the risk of developing CRC.
Publish Date	2018-09-28 00:52
Citation	Farhana L, Antaki F, Murshed F, Mahmud H, Judd SL, Nangia-Makker P, Levi E, Yu Y, Majumdar APN. Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans. World J Gastrointest Pathophysiol 2018; 9(2): 47-58
URL	http://www.wjgnet.com/2150-5330/full/v9/i2/47.htm
DOI	http://dx.doi.org/10.4291/wjgp.v9.i2.47

Full Article (PDF)	WJGP-9-47.pdf
The ARRIVE Guidelines	39764-The-ARRIVE-Guidelines.pdf
Manuscript File	39764-Review.doc
Answering Reviewers	39764-Answering reviewers.pdf
Audio Core Tip	39764-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	39764-Conflict-of-interest statement.pdf
Copyright License Agreement	39764-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	39764-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	39764-Institutional review board statement.pdf
Supplementary Material	39764-Supplementary-Material-revision.docx
Peer-review Report	39764-Peer-review(s).pdf
Scientific Misconduct Check	39764-Scientific misconduct check.pdf
Scientific Editor Work List	39764-Scientific editor work list.pdf