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8/13/2018 7:45:11 AM | Browse: 623 | Download: 668
Publication Name World Journal of Gastroenterology
Manuscript ID 39776
Country/Territory China
Received
2018-05-11 06:08
Peer-Review Started
2018-05-11 08:07
To Make the First Decision
2018-06-06 02:08
Return for Revision
2018-06-11 08:06
Revised
2018-06-17 08:28
Second Decision
2018-06-28 08:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-28 16:20
Articles in Press
2018-06-28 16:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-07 17:35
Typeset the Manuscript
2018-08-08 03:11
Publish the Manuscript Online
2018-08-13 07:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Engineering, Biomedical
Manuscript Type Basic Study
Article Title Novel sericin-based hepatocyte serum-free medium and sericin’s effect on hepatocyte transcriptome
Manuscript Source Unsolicited Manuscript
All Author List Yun Huang, Qing Peng, Hai-Yan Li, Zhi-Dong Jia, Yang Li and Yi Gao
ORCID
Author(s) ORCID Number
Yun Huang http://orcid.org/0000-0002-4247-8964
Qing Peng http://orcid.org/0000-0002-7790-6455
Hai-Yan Li http://orcid.org/0000-0002-3842-8964
Zhi-Dong Jia http://orcid.org/0000-0001-5362-5205
Yang Li http://orcid.org/0000-0003-4718-1825
Yi Gao http://orcid.org/0000-0003-3525-0133
Funding Agency and Grant Number
Funding Agency Grant Number
The National Natural Science Foundation of China 81470875
The Natural Science Foundation of Guangdong Province 2014A030312013
Science and Technology Planning Project of Guangdong Province 2014B020227002
Science and Technology Planning Project of Guangdong Province 2015B090903069
Science and Technology Planning Project of Guangdong Province 2015B020229002
Science and Technology Program of Guangzhou 201604020002
Corresponding Author Yi Gao, MD, PhD, Chief Doctor, Professor, Surgeon, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine,, Zhujiang Hospital of Southern Medical University, 253 Middle Industrial Avenue, Guangzhou 510280, Guangdong, China. gaoyi6146@163.com
Key Words Sericin; Serum-free medium; MAPK pathway; Bioartificial liver support system; CCR6
Core Tip In recent decades, few studies have focused on the development of hepatocyte serum-free medium. In this study, we developed a novel hepatocyte serum-free medium suitable for in vitro culture of C3A cells and applied an advanced method, gene-chip array, to explore the effect of sericin on the hepatocyte transcriptome. We found that sericin probably enhanced cell attachment through the CCR6-Akt-JNK-NF-κB pathway and promoted cell proliferation through CCR6-mediated activation of the ERK1/2-MAPK pathway. These findings inspired the fol­lowing study on the mechanism by which sericin promotes cell attachment and proliferation.
Publish Date 2018-08-13 07:45
Citation Huang Y, Peng Q, Li HY, Jia ZD, Li Y, Gao Y. novel sericin-based hepatocyte serum-free medium and sericin’s effect on hepatocyte transcriptome. World J Gastroenterol 2018; 24(30): 3398-3413
URL http://www.wjgnet.com/1007-9327/full/v24/i30/3398.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i30.3398
Full Article (PDF) WJG-24-3398.pdf
Manuscript File 39776-Review.docx
Answering Reviewers 39776-Answering reviewers.pdf
Audio Core Tip 39776-Audio core tip.mp3
Biostatistics Review Certificate 39776-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39776-Conflict-of-interest statement.pdf
Copyright License Agreement 39776-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 39776-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 39776-Language certificate.pdf
Peer-review Report 39776-Peer-review(s).pdf
Scientific Misconduct Check 39776-Scientific misconduct check.pdf
Scientific Editor Work List 39776-Scientific editor work list.pdf