Publication Name	World Journal of Gastroenterology
Manuscript ID	3984
Country	Brazil

Received	2013-06-06 08:38
Peer-Review Started	2013-06-07 19:01
To Make the First Decision	2013-06-24 10:30
Return for Revision	2013-07-01 13:18
Revised	2013-07-04 02:41
Second Decision	2013-07-18 17:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-07-19 01:36
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-29 20:05
Publish the Manuscript Online	2013-10-15 17:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pathology
Manuscript Type	Autobiography
Article Title	HER2 in gastric cancer: Comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays
Manuscript Source	Invited Manuscript
All Author List	Lucas Faria Abrahão-Machado, Alexandre Andrade dos Anjos Jácome, Durval Renato Wohnrath, José Sebastião dos Santos, Estela Cristina Carneseca, José Humberto Tavares Guerreiro Fregnani and Cristovam Scapulatempo-Neto
Funding Agency and Grant Number
Corresponding Author	Lucas Faria Abrahão-Machado, MD, Department of Pathology, Barretos Cancer Hospital, Rua Antenor Duarte Vilela, 1331, Barretos, Sao Paulo 14784-400, Brazil. lucasfariamachado@yahoo.com
Key Words	Gastric cancer; Human epidermalgrowth factor receptor 2; Immunohistochemistry; Whole-tissue sections; Tissue microarray; Trastuzumab
Core Tip	This is the first study to compare the three widely used anti-human epidermalgrowth factor receptor 2 (HER2) antibodies 4B5, SP3 and HercepTest in tissue microarrays and whole-tissue sections prepared from paraffin blocks of a single series of gastric tumors. We aimed to find the best method to assess HER2 expression in gastric cancer, facilitating the choice of the antibody with the greatest ability to identify the most patients who could benefit from the use of trastuzumab. Besides, we demonstrated that HER2 expression in small samples of gastric cancer (such as tissue microarrays and biopsies) should be evaluated cautiously because these tumors exhibit intratumoral heterogeneity that may influence the results.
Publish Date	2013-10-15 17:26
Citation	Abrah?o-Machado LF, Jácome AAA, Wohnrath DR, Santos JS, Carneseca EC, Fregnani JHTG, Scapulatempo-Neto C. HER2 in gastric cancer: Comparative analysis of three different antibodies using whole-tissue sections and tissue microarrays. World J Gastroenterol 2013; 19(38): 6438-6446
URL	http://www.wjgnet.com/1007-9327/full/v19/i38/6438.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i38.6438

Full Article (PDF)	WJG-19-6438.pdf
Manuscript File	3984-Review.doc
Answering Reviewers	3984-Answering reviewers.pdf
Copyright License Agreement	3984-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	3984-Language certificate.doc
Peer-review Report	3984-Peer review(s).pdf
Scientific Editor Work List	3984-Scientific editor work list.doc