Publication Name	World Journal of Gastroenterology
Manuscript ID	3986
Country	Canada

Received	2013-06-06 08:57
Peer-Review Started	2013-06-07 18:55
To Make the First Decision	2013-07-05 18:30
Return for Revision	2013-07-17 16:46
Revised	2013-08-09 22:36
Second Decision	2013-10-21 17:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-22 06:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-11-27 19:53
Typeset the Manuscript	2013-12-28 17:52
Publish the Manuscript Online	2014-01-20 17:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Time of infliximab therapy initiation and dose escalation in Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Mindy CW Lam, Terry Lee, Kenneth Atkinson and Brian Bressler
Funding Agency and Grant Number
Corresponding Author	Brian Bressler, MD, Division of Gastroenterology, Department of Medicine, University of British Columbia,770-1190 Hornby Street, Vancouver, BC V6Z 2K5, Canada. brian_bressler@hotmail.com
Key Words	Crohn’s disease; Infliximab; Dose escalation
Core Tip	Crohn’s disease patients who required infliximab therapy earlier (< 2 years) probably have a higher inflammatory burden of disease than those who require infliximab therapy later. Our results show that those who receive infliximab within 2 years of diagnosis require more intense immunosuppressant therapy to avoid dose escalation. This finding supports the importance of concurrent immunosuppressant therapy while on infliximab, as previously described by the SONIC trial.
Publish Date	2014-01-20 17:10
Citation	Lam MCW, Lee T, Atkinson K, Bressler B. Time of infliximab therapy initiation and dose escalation in Crohn’s disease. World J Gastroenterol 2014; 20(1): 214-218
URL	http://www.wjgnet.com/1007-9327/full/v20/i1/214.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i1.214

Full Article (PDF)	WJG-20-214.pdf
Full Article (Word)	WJG-20-214.doc
Manuscript File	3986-Review.docx
Answering Reviewers	3986-Answering reviewers.pdf
Copyright License Agreement	3986-Copyright assignment.pdf
Peer-review Report	3986-Peer reviewer(s).pdf
Scientific Editor Work List	3986-Scientific editor work list.doc