Publication Name	World Journal of Gastroenterology
Manuscript ID	39862
Country	United Kingdom

Received	2018-05-16 01:30
Peer-Review Started	2018-05-16 11:15
To Make the First Decision	2018-06-06 02:16
Return for Revision	2018-06-11 08:00
Revised	2018-07-08 11:17
Second Decision	2018-07-13 09:29
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2018-07-16 01:48
Articles in Press	2018-07-16 01:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-07-25 03:16
Publish the Manuscript Online	2018-07-27 06:43

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients
Manuscript Source	Invited Manuscript
All Author List	Bettina M Buchholz, Panagis M Lykoudis, Reena Ravikumar, Joerg M Pollok and Giuseppe Kito Fusai
ORCID	Author(s) ORCID Number Bettina M Buchholz http://orcid.org/0000-0002-5002-3302 Panagis M Lykoudis http://orcid.org/0000-0003-2170-0471 Reena Ravikumar http://orcid.org/0000-0002-2302-6452 Joerg M Pollok http://orcid.org/0000-0001-8771-4070 Giuseppe Kito Fusai http://orcid.org/0000-0002-8784-6919
Funding Agency and Grant Number
Corresponding Author	Giuseppe Kito Fusai, FRCS (Gen Surg), MSc, Surgeon, Department of HPB Surgery and Liver Transplantation, Royal Free Hospital, Pond Street, London NW32QG, United Kingdom. g.fusai@ucl.ac.uk
Key Words	Recurrent primary sclerosing cholangitis; Risk factor; Ulcerative colitis; Colectomy; Liver transplantation
Core Tip	There are no known treatments that can alter the development and/or progression of recurrent primary sclerosing cholangitis (rPSC) after liver transplantation (LT). Shared leukocyte recruitment pathways of the gut-liver axis, bacterial translocation into the portal circulation from an inflamed gut and intestinal dysbiosis might contribute to the pathogenesis of rPSC. Indeed, inflammatory bowel dis­ease, ulcerative colitis and in particular active colitis post-LT significantly increase the risk of rPSC and the available data favours a protective role of pre-/peri-LT co­lectomy in rPSC. Prospective studies and randomized trials are needed to further elucidate a possible mechanistic link between retained colon and rPSC.
Publish Date	2018-07-27 06:43
Citation	Buchholz BM, Lykoudis PM, Ravikumar R, Pollok JM, Fusai GK. Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients. World J Gastroenterol 2018; 24(28): 3171-3180
URL	http://www.wjgnet.com/1007-9327/full/v24/i28/3171.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i28.3171

Full Article (PDF)	WJG-24-3171.pdf
Manuscript File	39862-Review.docx
Answering Reviewers	39862-Answering reviewers.pdf
Audio Core Tip	39862-Audio core tip.mp3
Biostatistics Review Certificate	39862-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	39862-Conflict-of-interest statement.pdf
Copyright License Agreement	39862-Copyright license agreement.pdf
Supplementary Material	39862-Supplementary material.pdf
Peer-review Report	39862-Peer-review(s).pdf
Scientific Misconduct Check	39862-Scientific misconduct check.pdf
Scientific Editor Work List	39862-Scientific editor work list.pdf