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8/27/2018 7:22:43 AM | Browse: 267 | Download: 110
Publication Name World Journal of Gastroenterology
Manuscript ID 39864
Country/Territory China
Received
2018-05-18 09:30
Peer-Review Started
2018-05-19 13:35
To Make the First Decision
2018-06-06 02:20
Return for Revision
2018-06-11 08:52
Revised
2018-06-14 22:52
Second Decision
2018-06-26 11:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-27 04:03
Articles in Press
2018-06-27 04:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-03 01:19
Typeset the Manuscript
2018-08-27 01:40
Publish the Manuscript Online
2018-08-27 07:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Abnormal expression of HMGB-3 is significantly associated with malignant transformation of hepatocytes
Manuscript Source Unsolicited Manuscript
All Author List Wen-Jie Zheng, Min Yao, Miao Fang, Li Wang, Zhi-Zhen Dong and Deng-Fu Yao
ORCID
Author(s) ORCID Number
Wen-Jie Zheng http://orcid.org/0000-0002-3073-4596
Min Yao http://orcid.org/0000-0002-5473-0186
Miao Fang http://orcid.org/0000-0002-3211-6230
Li Wang http://orcid.org/0000-0003-2838-9807
Zhi-Zhen Dong http://orcid.org/0000-0001-8862-830x
Deng-Fu Yao http://orcid.org/0000-0002-3448-7756
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81673241
National Natural Science Foundation of China 81702419
Projects of Jiangsu Medical Science BE2016698
Jiangsu Graduate Innovation KYCX17_1934
Nantong Health and Family Planning Commission WQ2016083
National Int S&T Cooperation Program 2013DFA32150
Corresponding author Deng-Fu Yao, MD, PhD, Postdoc, Professor, director, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu, China. yaodf@ahnmc.com
Keywords Liver cancer; HMGB-3; Hepatocarcinogenesis; Proliferation; Tumor growth
Core Tip high mobility group box (HMGB) family pro­teins were correlated with hepatocellular carcinoma (HCC) development and progression. This current study examined the effects of HMGB3 on HCC both in vitro and in vivo. Overexpression of HMGB3 was observed in hepatic malignant transformation and HCC tissues in bioinformatic databases. Knockdown of HMGB3 significantly inhibited proliferation, cell cycle, and tumor growth of HCC cells, providing a novel insight for HCC research.
Publish Date 2018-08-27 07:22
Citation Zheng WJ, Yao M, Fang M, Wang L, Dong ZZ, Yao DF. Abnormal expression of HMGB-3 is significantly associated with malignant transformation of hepatocytes. World J Gastroenterol 2018; 24(32): 3650-3662
Url http://www.wjgnet.com/1007-9327/full/v24/i32/3650.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i32.3650
Full Article (PDF) WJG-24-3650.pdf
Manuscript File 39864-Review.docx
Answering Reviewers 39864-Answering reviewers.pdf
Audio Core Tip 39864-Audio core tip.m4a
Biostatistics Review Certificate 39864-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 39864-Conflict-of-interest statement.pdf
Copyright License Agreement 39864-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 39864-Institutional animal care and use committee statementment.pdf
Institutional Review Board Approval Form or Document 39864-Institutional Review Board Approval Form or Document.pdf
Non-Native Speakers of English Editing Certificate 39864-Language certificate.pdf
Peer-review Report 39864-Peer-review(s).pdf
Scientific Misconduct Check 39864-Scientific misconduct check.pdf
Scientific Editor Work List 39864-Scientific editor work list.pdf