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9/6/2018 1:33:44 AM | Browse: 99 | Download: 75
Publication Name World Journal of Gastroenterology
Manuscript ID 39865
Country of Manuscript Source Australia
Received
2018-05-22 11:05
Peer-Review Started
2018-05-23 07:34
To Make the First Decision
2018-06-06 02:06
Return for Revision
2018-06-11 07:53
Revised
2018-06-22 10:08
Second Decision
2018-06-27 09:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-06-27 17:23
Articles in Press
2018-06-27 17:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-08-31 09:12
Publish the Manuscript Online
2018-09-06 01:33
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation
Manuscript Source Unsolicited Manuscript
All Author List Kai Wang, Graham S Baldwin, Mehrdad Nikfarjam and Hong He
ORCID
Author(s) ORCID Number
Kai Wang http://orcid.org/0000-0003-4152-8752
Graham S Baldwin http://orcid.org/0000-0002-0944-8747
Mehrdad Nikfarjam http://orcid.org/0000-0003-4866-276X
Hong He http://orcid.org/0000-0002-2342-8750
Funding Agency and Grant Number
Correspondence To Hong He, MD, PhD, Senior Research Fellow, Department of Surgery, University of Melbourne, Austin Health, Studley Rd., Heidelberg, Victoria, Melbourne 3084, Australia. hong.he@unimelb.edu.au
Keywords Pancreatic cancer; Kras; p21-activated kinases; Cell signalling; Chemo-resistance; Immune response; Tumour microenvironment
Core Tip Pancreatic cancer is still one of the most lethal malignancies, with a five-year survival of less than 8%. The dismal prognosis is largely the result of reprogramming of the tumour microenvironment, which leads to chemo-resistance and high aggressiveness. So far, combination chemotherapies can only marginally improve patients’ survival, but with high toxicity. Therefore, alternative treatment targeting protein kinase signalling has been proposed. As downstream effectors of Kras signalling, p21-activated kinases (PAKs) are positioned at the nexus of multiple oncogenic signalling pathways. Here, the importance of PAKs as therapeutic targets in Kras signalling is discussed, and their essential role in tumour biology and immune modulation within the tumour microenvironment is highlighted.
Publish Date 2018-09-06 01:33
Citation Wang K, Baldwin GS, Nikfarjam M, He H. p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation. World J Gastroenterol 2018; 24(33): 3709-3723
Url http://www.wjgnet.com/1007-9327/full/v24/i33/3709.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i33.3709
Full Article (PDF) WJG-24-3709.pdf
Full Article (Word) WJG-24-3709.doc
Manuscript File 39865-Review.docx
Answering Reviewers 39865-Answering reviewers.pdf
Audio Core Tip 39865-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39865-Conflict-of-interest statement.pdf
Copyright License Agreement 39865-Copyright license agreement.pdf
Peer-review Report 39865-Peer-review(s).pdf
Scientific Misconduct Check 39865-Scientific misconduct check.pdf
Scientific Editor Work List 39865-Scientific editor work list.pdf