| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Isolation and characterization of a new candidate human inactivated rotavirus vaccine strain from hospitalized children in Yunnan, China: 2010-2013
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Yuan Wu, Yan Zhou, Guang-Ming Zhang, Guo-Fa Mu, Shan Yi, Xiao-Chen Lin, Yu-Ping Xie, Na Yin, Hong-Jun Li and Mao-Sheng Sun |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the CAMS Initiative for Innovative Medicine |
2016-I2M-1-019 |
| National Natural Science Foundation of China |
31700154 |
| Major Science and Technology Special Project of Yunnan Province (Biomedicine) |
2018ZF006 |
| Science and Technology Project of Yunnan Province—general program |
2016FB034 |
| The State Project for Essential Drug Research and Development, the national “Twelfth Five-Year” plan |
2014ZX09102041004 |
| the CAMS Initiative for Innovative Medicine |
2016-I2M-3-026 |
|
| Corresponding Author |
Hong-Jun Li, PhD, Full Professor, Department of Molecular Biology, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, No. 935 Jiaoling Road, Kunming 650118, Yunnan Province, China. lihj6912@hotmail.com |
| Key Words |
Rotavirus; Genotype G; G1P[8]; Inactivated rotavirus vaccine; Genotype characterization; Rapid antigen detection kit; Phylogenetic analysis |
| Core Tip |
A high prevalence of the G1, G2, and G3 genotypes was detected from 2010 to 2012. However, a dominant prevalence of the G9 genotype was identified as the cause of gastroenteritis in children in Yunnan, China, in 2013. A candidate human inactivated rotavirus vaccine strain, designated ZTR-68 was isolated, characterized, and showed immunogenicity. Our data will be useful for the future formulation and development of a new inactivated rotavirus vaccine in China. |
| Publish Date |
2018-09-28 10:31 |
| Citation |
Wu JY, Zhou Y, Zhang GM, Mu GF, Yi S, Yin N, Xie YP, Lin XC, Li HJ, Sun MS. Isolation and characterization of a new candidate human inactivated rotavirus vaccine strain from hospitalized children in Yunnan, China: 2010-2013. World J Clin Cases 2018; 6(11): 426-440 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i11/426.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i11.426 |
