Publication Name	World Journal of Critical Care Medicine
Manuscript ID	3991
Country	Canada

Received	2013-06-06 20:20
Peer-Review Started	2013-06-07 11:18
To Make the First Decision	2013-07-19 08:49
Return for Revision	2013-07-20 23:30
Revised
Second Decision	2013-12-13 13:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-12-13 14:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-26 16:48
Publish the Manuscript Online	2014-02-16 13:23

ISSN	2220-3141(online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Controversies in fluid therapy: Type, dose and toxicity
Manuscript Source	Invited Manuscript
All Author List	Robert C McDermid, Karthik Raghunathan, Adam Romanovsky, Andrew D Shaw and Sean M Bagshaw
Funding Agency and Grant Number	Funding Agency Grant Number Canada Research Chair in Critical Care Nephrology Clinical Investigator Award from Alberta Innovates-Health Solutions (to Bagshaw MS)
Corresponding Author	Dr. Sean M Bagshaw, Division of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta, 3C1.12 Walter C. Mackenzie Centre, 8440-122 ST NW, Edmonton, AB T6G2B7, Canada. bagshaw@ualberta.ca
Key Words	Fluid therapy; Resuscitation; Critical illness; Peri-operative; Toxicity; Saline; Crystalloid; Colloid
Core Tip	Fluid therapy is exceedingly common in acutely ill patients; however, numerous questions on the efficacy and safety of fluid therapy in terms of the type and dose remain. Fluid therapy prescription is context-specific and any fluid type can be harmful if administered inappropriately. When considering crystalloids versus colloids, differences in efficacy are modest but the risk of kidney toxicity and bleeding complications with hydroxyethyl starch appear more significant. The differences in chloride load across crystalloid solutions appears to have physiologic and clinically important effects, in particular for contributing to hyperchloremic metabolic acidosis, kidney injury and greater utilization of renal replacement therapy associated with 0.9% saline. Fluid therapy should be viewed as analogous to the prescription of any drug in acutely ill patients.
Publish Date	2014-02-16 13:23
Citation	McDermid RC, Raghunathan K, Romanovsky A, Shaw AD, Bagshaw SM. Controversies in fluid therapy: Type, dose and toxicity. World J Crit Care Med 2014; 3(1): 24-33 Available from: URL: http://www.wjgnet.com/2220-3141/full/v3/i1/24.htm DOI: http:// dx.doi.org/10.5492/wjccm.v3.i1.24
URL	http://www.wjgnet.com/2220-3141/full/v3/i1/24.htm
DOI	http://dx.doi.org/10.5492/wjccm.v3.i1.24

Full Article (PDF)	WJCCM-3-24.pdf
Full Article (Word)	WJCCM-3-24.doc
Manuscript File	3991-Review.doc
Answering Reviewers	3991-Answering reviewers.pdf
Copyright License Agreement	3991-Copyright assignment.pdf
Peer-review Report	3991-Peer reviewer(s).pdf
Scientific Editor Work List	3991-Scientific editor work list.doc