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Articles Published Processes
9/30/2018 7:38:56 AM | Browse: 1684 | Download: 2589
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Received |
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2018-05-27 06:04 |
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Peer-Review Started |
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2018-05-27 09:28 |
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First Decision by Editorial Office Director |
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2018-07-03 16:54 |
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Return for Revision |
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2018-07-06 07:08 |
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Revised |
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2018-08-07 13:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2018-08-20 06:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2018-08-24 09:30 |
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Articles in Press |
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2018-08-24 09:30 |
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Edit the Manuscript by Language Editor |
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2018-09-05 18:05 |
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Typeset the Manuscript |
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2018-09-26 08:33 |
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Publish the Manuscript Online |
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2018-09-30 07:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Basic Study |
| Article Title |
VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chun-Sai-Er Wang, Wen-Bin Li, Hong-Ying Wang, Yi-Ming Ma, Xin-Hua Zhao, Hong Yang, Jia-Ming Qian and Jing-Nan Li |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jing-Nan Li, MD, Doctor, Doctor, Department of Gastroenterology, PUMC Hospital, CAMS and PUMC, No.1 Shuai Fu Yuan, Beijing 100730, China. lijn@pumch.cn |
| Key Words |
Tumor necrosis factor-α; VSL#3; Ulcerative colitis carcinogenesis; Interleukin-6; Intestinal microbiota |
| Core Tip |
Microbiota and chronic inflammation play an important role in the process of ulcerative colitis (UC)-associated carcinogenesis. Our study found VSL#3 could effectively prevent UC-associated carcinogenesis in azoxymethane/dextran sulfate sodium induced mice and decrease the level of tumor necrosis factor-α and IL-6 in colon tissue. The intestinal microbiota dysbiosis exists in UC-associated carcinogenesis. Supplementary VSL#3 is beneficial for rebalancing the fecal and mucosal intestinal microbiota. Based on the data presented here, VSL#3 may be a potential therapeutic agent for UC-associated carcinogenesis prevention. |
| Publish Date |
2018-09-30 07:38 |
| Citation |
Wang CS, Li WB, Wang HY, Ma YM, Zhao XH, Yang H, Qian JM, Li JN. VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice. World J Gastroenterol 2018; 24(37): 4254-4262 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i37/4254.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i37.4254 |
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