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9/14/2018 5:53:04 AM | Browse: 607 | Download: 749
Publication Name World Journal of Gastroenterology
Manuscript ID 39989
Country/Territory Thailand
Received
2018-05-25 08:00
Peer-Review Started
2018-05-25 22:48
To Make the First Decision
2018-06-21 01:34
Return for Revision
2018-06-29 12:34
Revised
2018-07-05 15:18
Second Decision
2018-07-13 09:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-07-16 01:41
Articles in Press
2018-07-16 01:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-07-21 23:06
Typeset the Manuscript
2018-09-03 08:09
Publish the Manuscript Online
2018-09-14 05:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication
Manuscript Source Unsolicited Manuscript
All Author List Areerat Kunanopparat, Jiraphorn Issara-Amphorn, Asada Leelahavanichkul, Anapat Sanpavat, Suthiluk Patumraj, Pisit Tangkijvanich, Tanapat Palaga and Nattiya Hirankarn
ORCID
Author(s) ORCID Number
Areerat Kunanopparat http://orcid.org/0000-0001-6311-7255
Jiraphorn Issara-Amphorn http://orcid.org/0000-0002-7421-2749
Asada Leelahavanichkul http://orcid.org/0000-0002-5566-6403
Anapat Sanpavat http://orcid.org/0000-0002-6425-3379
Suthiluk Patumraj http://orcid.org/0000-0002-8346-2205
Pisit Tangkijvanich http://orcid.org/0000-0002-2926-8671
Tanapat Palaga http://orcid.org/0000-0001-8734-6626
Nattiya Hirankarn http://orcid.org/0000-0003-2224-6856
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Council of Thailand 2013
the Ratchadaphiseksomphot Matching Fund from the Faculty of Medicine, Chulalongkorn University
the International Research Integration, Chula Research Scholar, Ratchadaphisek somphot Endowment Fund, Center of Excellence in Immunology and Immune-mediated Diseases
the Rachadapisaek Sompote Post-Doctoral Fund, Chulalongkorn University
Corresponding Author Nattiya Hirankarn, MD, PhD, Lecturer, Professor, Center of Excellence in Immunology and Immune Mediated Diseases, Chulalongkorn University, 1873 Rama 4 Road, Khwaeng Pathum Wan, Khet Pathum Wan, Bangkok 10330, Thailand. nattiya.h@chula.ac.th
Key Words hepatocellular carcinoma; Notch signalling; Delta-like ligand 4; HepG2.2.15
Core Tip We demonstrated that Delta-like ligand 4 (DLL4) is important for tumour growth of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) in a xenograft model. We found that the level of angiogenesis regulators, VEGF-A and VEGF-R2 were significantly decreased in HCC xenograft tumours with suppressed DLL4 compared with the control group. Consistent with these findings, the suppression of DLL4 expression in the tumour cells reduced cell proliferation and the formation of new blood vessels in the tumour. Furthermore, this is the first report that DLL4 in an HBV expressing HCC cell line plays a key role in regulating tumour growth, angiogenesis, and viral replication in a mouse model of xenograft transplantation.
Publish Date 2018-09-14 05:53
Citation Kunanopparat A, Issara-Amphorn J, Leelahavanichkul A, Sanpavat A, Patumraj S, Tangkijvanich P, Palaga T, Hirankarn N. Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication. World J Gastroenterol 2018; 24(34): 3861-3870
URL http://www.wjgnet.com/1007-9327/full/v24/i34/3861.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i34.3861
Full Article (PDF) WJG-24-3861.pdf
The ARRIVE Guidelines 39989-The ARRIVE guidelines.pdf
Manuscript File 39989-Review.docx
Answering Reviewers 39989-Answering reviewers.pdf
Audio Core Tip 39989-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 39989-Conflict-of-interest statement.pdf
Copyright License Agreement 39989-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 39989-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 39989-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 39989-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 39989-Language certificate.pdf
Peer-review Report 39989-Peer-review(s).pdf
Scientific Misconduct Check 39989-Scientific misconduct check.pdf
Scientific Editor Work List 39989-Scientific editor work list.pdf