ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Areerat Kunanopparat, Jiraphorn Issara-Amphorn, Asada Leelahavanichkul, Anapat Sanpavat, Suthiluk Patumraj, Pisit Tangkijvanich, Tanapat Palaga and Nattiya Hirankarn |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Research Council of Thailand 2013 |
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the Ratchadaphiseksomphot Matching Fund from the Faculty of Medicine, Chulalongkorn University |
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the International Research Integration, Chula Research Scholar, Ratchadaphisek somphot Endowment Fund, Center of Excellence in Immunology and Immune-mediated Diseases |
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the Rachadapisaek Sompote Post-Doctoral Fund, Chulalongkorn University |
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Corresponding Author |
Nattiya Hirankarn, MD, PhD, Lecturer, Professor, Center of Excellence in Immunology and Immune Mediated Diseases, Chulalongkorn University, 1873 Rama 4 Road, Khwaeng Pathum Wan, Khet Pathum Wan, Bangkok 10330, Thailand. nattiya.h@chula.ac.th |
Key Words |
hepatocellular carcinoma; Notch signalling; Delta-like ligand 4; HepG2.2.15 |
Core Tip |
We demonstrated that Delta-like ligand 4 (DLL4) is important for tumour growth of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) in a xenograft model. We found that the level of angiogenesis regulators, VEGF-A and VEGF-R2 were significantly decreased in HCC xenograft tumours with suppressed DLL4 compared with the control group. Consistent with these findings, the suppression of DLL4 expression in the tumour cells reduced cell proliferation and the formation of new blood vessels in the tumour. Furthermore, this is the first report that DLL4 in an HBV expressing HCC cell line plays a key role in regulating tumour growth, angiogenesis, and viral replication in a mouse model of xenograft transplantation. |
Publish Date |
2018-09-14 05:53 |
Citation |
Kunanopparat A, Issara-Amphorn J, Leelahavanichkul A, Sanpavat A, Patumraj S, Tangkijvanich P, Palaga T, Hirankarn N. Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication. World J Gastroenterol 2018; 24(34): 3861-3870 |
URL |
http://www.wjgnet.com/1007-9327/full/v24/i34/3861.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v24.i34.3861 |