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Articles Published Processes
10/12/2018 5:32:21 AM | Browse: 1159 | Download: 1765
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Received |
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2018-06-21 03:38 |
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Peer-Review Started |
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2018-06-21 07:36 |
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To Make the First Decision |
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2018-08-01 02:48 |
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Return for Revision |
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2018-08-01 07:16 |
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Revised |
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2018-08-06 16:53 |
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Second Decision |
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2018-08-20 06:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2018-08-24 09:19 |
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Articles in Press |
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2018-08-24 09:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2018-10-04 02:01 |
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Publish the Manuscript Online |
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2018-10-12 05:32 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Natalia Schneider Nunes, Saejeong Kim, Maggie Sundby, Parwathy Chandran, Scott Robert Burks, Ana Helena Paz and Joseph Alan Frank |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Natalia Schneider Nunes, MSc, Research Fellow, Frank Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bldg 10 Room B1N256, 10 Center Drive, Bethesda, MD 20982, United States. natalia.schneidernunes@nih.gov |
| Key Words |
Ulcerative colitis; Dextran sulfate sodium; Proteomics; Inflammatory bowel diseases; Inflammation |
| Core Tip |
Our study contributes to a better understanding of the dextran sulfate sodium (DSS) acute colitis model in order to provide a stronger basis for novel therapies. Colonic proteomic temporal analysis reveals an increase in cytokines with a strong influx of immune cells. The highest cytokine levels were observed when animals were no longer drinking DSS, suggesting a rebound response. Secondary lymphoid organs contribute by sending different immune cells to the colon during the acute phase, such as CD4+, CD8+ and CD25+ T cells. Our results demonstrate involvement of the adaptive and innate immune responses during the acute phase of DSS-induced colitis. |
| Publish Date |
2018-10-12 05:32 |
| Citation |
Nunes NS, Kim S, Sundby M, Chandran P, Burks SR, Paz AH, Frank JA. Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis. World J Gastroenterol 2018; 24(38): 4341-4355 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i38/4341.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i38.4341 |
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