Publication Name	World Journal of Hepatology
Manuscript ID	40193
Country	Iran

Received	2018-06-07 00:28
Peer-Review Started	2018-06-07 09:17
First Decision by Editorial Office Director	2018-07-11 21:28
Return for Revision	2018-07-12 07:15
Revised	2018-07-19 11:32
Publication Fee Transferred
Second Decision by Editor	2018-08-02 10:56
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2018-08-04 20:31
Articles in Press	2018-08-04 20:31
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-09-25 03:22
Publish the Manuscript Online	2018-09-27 09:38

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Hepatitis C resistance to NS5A inhibitors: Is it going to be a problem?
Manuscript Source	Invited Manuscript
All Author List	Heidar Sharafi and Seyed Moayed Alavian
ORCID	Author(s) ORCID Number Heidar Sharafi http://orcid.org/0000-0001-9177-9117 Seyed Moayed Alavian http://orcid.org/0000-0002-4443-6602
Funding Agency and Grant Number
Corresponding Author	Heidar Sharafi, BSc, MA, MPhil, MSc, PhD, Research Scientist, Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran 1415513651, Iran. h.sharafi@meldcenter.com
Key Words	Direct-acting antiviral agent; Hepatitis C; NS5A; Resistance; Treatment
Core Tip	Hepatitis C virus resistance to NS5A inhibitors is one of the main problems of treatment with NS5A inhibitors. While the treatment of NS5A inhibitor-naïve patients is feasible and efficient, retreatment of NS5A inhibitor-experienced patients is challenging. In the con­text of failure following treatment with NS5A inhibitor-containing regimens, NS5A resistance-associated subs­titution testing can help in clinical decision-making, while the usefulness of baseline NS5A resistance-associated substitution testing in NS5A inhibitor-naïve patients is in question.
Publish Date	2018-09-27 09:38
Citation	Sharafi H, Alavian SM. Hepatitis C resistance to NS5A inhibitors: Is it going to be a problem? World J Hepatol 2018; 10(9): 543-548
URL	http://www.wjgnet.com/1948-5182/full/v10/i9/543.htm
DOI	http://dx.doi.org/10.4254/wjh.v10.i9.543

Full Article (PDF)	WJH-10-543.pdf
Full Article (Word)	WJH-10-543.doc
Manuscript File	40193-Review.docx
Answering Reviewers	40193-Answering reviewers.pdf
Audio Core Tip	40193-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	40193-Conflict-of-interest statement.pdf
Copyright License Agreement	40193-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	40193-Language certificate.pdf
Peer-review Report	40193-Peer-review(s).pdf
Scientific Misconduct Check	40193-Scientific misconduct check.pdf
Scientific Editor Work List	40193-Scientific editor work list.pdf