| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Larissa Lucena Périco, Vinicius Peixoto Rodrigues, Rie Ohara, Gabriela Bueno, Vânia Vasti Alfieri Nunes, Raquel Cássia dos Santos, Ana Carolina Lima Camargo, Luis Antônio Justulin Júnior, Sérgio Faloni de Andrade, Viviane Miranda Bispo Steimbach, Luísa Mota da Silva, Lúcia Regina Machado da Rocha, Wagner Vilegas, Catarina dos Santos and Clélia Akiko Hiruma-Lima |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FAPESP |
2015/14797-3 |
| Biota/FAPESP |
2009/52237-9 |
| CNPq |
306209/2016 |
|
| Corresponding Author |
Clélia Akiko Hiruma-Lima, PhD, Academic Research, Adjunct Professor, Department of Physiology, Institute of Biosciences, Botucatu 18618-970, Sao Paulo, Brazil. clelia.hiruma@unesp.br |
| Key Words |
Eugenia punicifolia; Gastric ulcer healing; Acetic acid; Sex difference; Myrtaceae; Toxicity |
| Core Tip |
Gastric ulcers, which occur due to an imbalance between protective and aggressive agents at the gastric mucosa surface, is a chronic disease that affects millions worldwide and has high rates of relapse. The conventional treatment for gastric ulcers is associated with several side effects and poor healing of the gastric mucosa. Eugenia punicifolia is a medicinal plant used to treat inflammation and wounds. The present study in rats with gastric ulcers confirms the healing effect of Eugenia punicifolia extract and clarifies its differential effect in males and females. These findings are useful for developing novel and safe therapies for gastric ulcers. |
| Publish Date |
2018-10-12 05:32 |
| Citation |
Périco LL, Rodrigues VP, Ohara R, Bueno G, Nunes VV, Santos RC, Camargo AC, Justulin LA, de Andrade SF, Steimbach VM, da Silva LM, da Rocha LR, Vilegas W, dos Santos C, Hiruma-Lima CA. Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats. World J Gastroenterol 2018; 24(38): 4369-4383 |
| URL |
http://www.wjgnet.com/1007-9327/full/v24/i38/4369.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v24.i38.4369 |
