Publication Name	World Journal of Medical Genetics
Manuscript ID	4030
Country	United Kingdom

Received	2013-06-13 18:56
Peer-Review Started	2013-06-14 08:50
To Make the First Decision	2013-08-21 18:54
Return for Revision	2013-08-26 09:43
Revised	2013-09-06 22:26
Second Decision	2013-09-18 11:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-18 11:41
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-10-18 00:44
Publish the Manuscript Online	2013-12-16 13:25

ISSN	2220-3184 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Regulation of the cell fate by DNA damage and hypoxia
Manuscript Source	Invited Manuscript
All Author List	Ramkumar Rajendran, Marija Krstic-Demonacos and Constantinos Demonacos
Funding Agency and Grant Number
Corresponding Author	Constantinos Demonacos, PhD, Lecturer, Principal Investigator, Molecular Pharmacology and Cancer Biology, Faculty of Medical and Human Sciences, Manchester Pharmacy School, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom. cdemonacos@manchester.ac.uk
Key Words	Cancer; Transcription; Apoptosis; Inflammation; Tumor energy metabolism; Glycolysis; Oxidative phosphorylation; p53; Hypoxia-inducible factor; p300/CBP associated factors
Core Tip	The results of our work endorse the notion that specific features determine targeting of transcription factors to distinct clusters of their target genes including the nature of the DNA binding sites found within the regulatory region of the promoter of each one of the target genes, the composition of the cofactor network associated with different transcription factors under diverse types of stress conditions and the precise posttranslational modifications of each one of the transcription factors linking characteristic PTM codes with discrete types of micro-environmental stress. These features are essential considerations for the design of effective therapeutics and individualised cancer treatment.
Publish Date	2013-12-16 13:25
Citation	Rajendran R, Krstic-Demonacos M, Demonacos C. Regulation of the cell fate by DNA damage and hypoxia. World J Med Genet 2013; 3(4): 34-40
URL	http://www.wjgnet.com/2220-3184/full/v3/i4/34.htm
DOI	http://dx.doi.org/10.5496/wjmg.v3.i4.34

Full Article (PDF)	WJMG-3-34.pdf
Full Article (Word)	WJMG-3-34.doc
Manuscript File	4030-Review.doc
Answering Reviewers	4030-Answering reviewers.pdf
Copyright License Agreement	4030-Copyright assignment.doc
Peer-review Report	4030-Peer reviewer(s).pdf
Scientific Editor Work List	4030-Scientific editor work list.doc